Senior Scientist, Lab Automation & ADME Discovery

Sotalent; Cambridge (MA); Sur place; USD 137 000 - 215 000; Plein temps

Résumé du poste

Sotalent in Cambridge, MA is seeking an experienced Senior Scientist to join Discovery Automation and Robotics. You will design, implement, and operate high-throughput in vitro ADME assays bridging traditional ADME with automation technology.

Responsibilities include leading automation initiatives, mentoring junior staff, driving miniaturization for throughput and cost efficiency, and collaborating with medicinal chemistry, DMPK, and data science teams to support discovery programs.

Qualifications

• PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related field with at least 3 years of experience.
• Experience with ADME method development and validation.
• Hands-on experience with laboratory robotics and automated liquid handling platforms.
• Experience in a service-oriented environment (CRO or centralized resource).
• Proven track record in miniaturizing assays for high-throughput settings.
• Familiarity with LIMS, ELN, and data visualization software.
• Understanding of how ADME data links to discovery cycles and PK/PD modeling.
• Experience supporting both small and large molecule programs is desirable.

Responsabilités

• Develop and maintain a comprehensive suite of in vitro ADME assays including metabolic stability, physiochemical characterization, permeability, and protein binding.
• Lead laboratory automation initiatives by integrating liquid handlers, robotic arms, and plate readers into end-to-end workflows.
• Mentor junior scientists and research associates to ensure operational excellence and scientific rigor.
• Drive assay miniaturization projects to improve throughput and reduce costs without sacrificing data quality.
• Collaborate across functions with medicinal chemistry, DMPK, and data science teams to ensure assay outputs support discovery programs and machine learning initiatives.
• Oversee data integrity and manage KPIs related to cycle time, capacity, and reproducibility.
• Manage the entire assay lifecycle from initial validation through to high volume production.

Connaissances

ADME method development

laboratory automation

data visualization software

mentoring

cross-functional collaboration

Formation

PhD in Pharmaceutical Sciences/Biochemistry/Pharmacology (or related)

Master degree (with 9+ years)

Bachelor degree (with 11+ years)

Outils

Laboratory robotics

Automated liquid handling platforms

LIMS/ELN familiarity

Plate readers

Description du poste

Sotalent in Cambridge, MA is seeking an experienced Senior Scientist to join Discovery Automation and Robotics. You will design, implement, and operate high-throughput in vitro ADME assays bridging traditional ADME with automation technology.

Responsibilities include leading automation initiatives, mentoring junior staff, driving miniaturization for throughput and cost efficiency, and collaborating with medicinal chemistry, DMPK, and data science teams to support discovery programs.