Senior Scientist l, QTAS & ADME Sciences

AbbVie; North Chicago (IL); On-site; USD 80,000 - 110,000; Full time

Benefits offered by this job

Paid time off

Medical/dental/vision insurance

401(k) participation

Job summary

AbbVie is looking for a highly motivated scientist to join the Quantitative, Translation & ADME Sciences team in North Chicago. The role involves laboratory experimentation, evaluating in vitro tools, and applying quantitative approaches to advance drug metabolism understanding.

The ideal candidate will have a strong background in drug metabolizing enzyme function, excellent communication skills, and relevant educational qualifications. AbbVie offers a comprehensive benefits package and opportunities for career growth.

Qualifications

• Bachelor's or Master's Degree with relevant experience is required.
• Strong background in drug metabolism and ADME principles.
• Excellent communication and presentation skills.

Responsibilities

• Conduct laboratory experimentation in cellular and subcellular models.
• Evaluate and improve prediction methods for drug interactions.
• Collaborate with cross-functional teams to support data generation.

Skills

Laboratory experimentation

Drug metabolism understanding

Cell culture methods

Communication skills

Team collaboration

Education

Bachelor’s Degree with 10 years of experience or PhD with no experience

Job description

AbbVie is seeking a highly motivated and experienced scientist to join our Quantitative, Translation & ADME Sciences (QTAS) team in North Chicago. The ideal candidate will have a strong background and expertise with in vitro models, drug metabolizing enzyme function, drug-drug interaction concepts, quantitative bioanalysis and the ability to spot, ideate and drive cutting‑edge science. Experience in adjacent areas such as drug permeability and transport, receptor pharmacology and pharmacokinetic modeling is desirable. In this role, you will participate in implementing innovative and quantitative approaches to advance translational ADME using conventional as well as more complex in vitro models. Working primarily in a laboratory, the position will involve conducting and contributing to scientific leadership of in vitro assays and applying translational modeling concepts to help drive AbbVie’s global in vitro ADME strategy. You will qualify, confirm and evaluate new technologies and execute operational activities to support the mechanistic and translational understanding of early and late‑stage small molecules to help advance drug candidates in our pipeline. Opportunities exist to contribute to broader areas within DMPK as your experience and expertise warrant.

Core responsibilities

• Laboratory experimentation in cellular and subcellular models.
• Evaluating novel in vitro tools and methods, and applying established methods and concepts to enable and improve prediction of human PK and drug-drug interaction potential.
• As needed, liaise with QTAS, discovery biology and pharmacology to generate data and knowledge supporting the build‑up of translational, mechanistic models.
• Communicate internally and externally on topics related to in vitro drug metabolism.
• Keep up to date with emerging literature and science in modeling and in vitro approaches.

Qualifications

• Bachelor’s Degree or equivalent education and typically 10 years of experience; Master’s Degree or equivalent education and typically 8 years of experience; PhD and no experience necessary.
• Strong experience in cell culture methods, including hepatocytes and cell lines.
• Deep understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment.
• Strong and relevant publication record.
• Highly motivated, self‑driven and results‑oriented person with excellent communication and presentation skills, capable to work both as a team player and independent scientific contributor.
• Passion for generating ideas, learning, solving technical problems and applying new technologies to further scientific goals.

Key leadership competencies

• Builds strong relationships with peers and cross‑functionally with partners outside the team to enable higher performance.
• Ability to inspire and lead others in areas of your expertise.
• Learns fast, grasps the “essence” and can change course quickly where indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Additional information – compensation and benefits

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and the Company may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.