Senior Scientist l, QTAS & ADME Sciences

BioSpace; North Chicago (IL); On-site; USD 120,000 - 170,000; Full time

Benefits offered by this job

Paid time off

Medical/dental/vision insurance

401(k)

Job summary

AbbVie seeks a highly motivated scientist to join the Quantitative, Translation & ADME Sciences (QTAS) team in North Chicago. You will lead in vitro assays, apply translational modeling, and evaluate new technologies to support mechanistic ADME understanding of drug candidates.

Strong publication record and excellent communication are required. The role emphasizes laboratory work, collaboration with discovery biology/pharmacology, and contribution to global in vitro ADME strategies to advance

Qualifications

• Bachelor’s degree or higher with extensive ADME experience.
• Experience with hepatocytes and cell lines.
• Knowledge of IVIVE and DDI risk assessment.
• Strong publication record.
• Excellent communication and ability to work as a team member and independently.

Responsibilities

• Laboratory experiments in cellular and subcellular models.
• Evaluate in vitro tools for prediction of human PK and DDI potential.
• Collaborate with QTAS and biology teams to build translational models.
• Communicate findings on in vitro drug metabolism internally and externally.
• Stay current with literature and modeling approaches.

Skills

Cell culture

Hepatocytes

Enzyme kinetics

IVIVE

DDI risk assessment

Communication

Independent contributor

Education

Bachelor/Master/PhD (ADME or related)

Job description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Company Description

About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

AbbVie is seeking a highly motivated and experienced scientist to join our Quantitative, Translation & ADME Sciences (QTAS) team in North Chicago. The ideal candidate will have a strong background and expertise with in vitro models, drug metabolizing enzyme function, drug-drug interaction concepts, quantitative bioanalysis and ability to spot, ideate and drive cutting-edge science. Applicants having experience in an adjacent area, such as drug permeability and transport, receptor pharmacology and pharmacokinetic modeling is desirable. In this exciting role, you will be expected to participate in implementing innovative and quantitative approaches to advance translational ADME using conventional as well as more complex in vitro models. Working primarily in a laboratory, the position will involve the conduct and contribution to scientific leadership of in vitro assays as well as applying translational modeling concepts to help drive the global in vitro ADME strategy at AbbVie. The candidate will be expected to qualify, confirm and evaluate new technologies as well as execute operational activities to support the mechanistic and translational understanding of early and late-stage small molecules to help advance drug candidates in our pipeline. In addition, you will have opportunities to contribute to broader areas within DMPK as your experience and expertise warrants.

Core Responsibilities Include

• Laboratory experimentation in cellular and subcellular models
• Evaluating novel in vitro tools and methods, and apply established methods and concepts to enable and improve prediction of human PK and drug-drug interaction potential
• As needed, liaise with QTAS, discovery biology/pharmacology to generate data and knowledge supporting the build-up of translational, mechanistic models
• Communicate internally and externally on topics related to in vitro drug metabolism
• Keep up to date with emerging literature and science in modeling and in vitro approaches

Qualifications

• Bachelors Degree or equivalent education and typically 10 years of experience, Masters Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary.
• Strong experience in cell culture methods, including hepatocytes and cell lines.
• Deep understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment
• Strong and relevant publication record
• Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as team player and independent scientific contributor
• Passion for generating ideas, learning, solving technical problems and applying new technologies to further scientific goals.

Key Leadership Competencies

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
• Ability to inspire and lead others in areas of your expertise
• Learns fast, grasps the "essence" and can change course quickly where indicated
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment, open to suggestions and experimentation for improvement
• Embraces the ideas of others, nurtures innovation and manages innovation to reality

Additional Information

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employer remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html