Principal Scientist, Chemical Biology & Proximity

BioSpace; Thousand Oaks (CA); On-site; USD 180,000 - 240,000; Full time

Benefits offered by this job

Competitive benefits

Job summary

Amgen seeks a Principal Scientist to lead discovery at the intersection of chemical biology and induced proximity, focusing on molecular glue discovery in disease-relevant systems. You will integrate phenotypic screening, chemical genetics, and mechanistic biology to uncover new therapeutic opportunities.

The role emphasizes collaboration across teams, development of disease-relevant cellular models, and translating findings into drug discovery programs, with a strong emphasis on proximity

Qualifications

• Doctorate degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field [and relevant post‑doc where applicable] and 2 years of relevant industry experience
• OR
• Masters degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 5 years of relevant industry experience
• OR
• Bachelors degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 7 years of relevant industry experience
• Strong expertise in chemical biology and small molecule discovery, with experience in proximity‑based mechanisms, molecular glues, or related areas
• Demonstrated experience developing and executing phenotypic screening assays, including high‑content or high‑throughput platforms

Responsibilities

• Lead discovery efforts using phenotypic screening and chemical genetics approaches to identify novel proximity-driven mechanisms
• Develop and apply disease-relevant cellular models to uncover actionable biology
• Integrate chemical biology and mechanistic studies to translate phenotypic findings into drug discovery programs
• Contribute to a growing portfolio of induced proximity-based therapeutic opportunities
• Design and implement phenotypic screening strategies to enable discovery of molecular glues and proximity-based modulators
• Partner with cross‑functional teams to advance discoveries from screening through early drug discovery

Skills

Chemical biology

Phenotypic screening

Molecular glue discovery

Induced proximity

Mechanistic biology

Cross-functional collaboration

Proteomics

Transcriptomics

Target deconvolution

Education

Doctorate in Chemical Biology/related field

Master's in Chemical Biology/related field

Bachelor's in Chemical Biology/related field

Job description

Amgen seeks a Principal Scientist to lead discovery at the intersection of chemical biology and induced proximity, focusing on molecular glue discovery in disease-relevant systems. You will integrate phenotypic screening, chemical genetics, and mechanistic biology to uncover new therapeutic opportunities.

The role emphasizes collaboration across teams, development of disease-relevant cellular models, and translating findings into drug discovery programs, with a strong emphasis on proximity