Principal Scientist, Proximity-Based Drug Discovery

St Jude Children's Research Hospital; Memphis (TN); On-site; USD 138,000 - 262,000; Full time

Job summary

St. Jude Children's Research Hospital seeks a Principal Scientist to direct our Chemical Induced Proximity Center within the Department of Chemical Biology and Therapeutics.

The role leads strategic drug discovery programs leveraging PROTACs, molecular glues, and other bifunctional approaches, guiding cross-functional collaborations and ensuring translational impact for pediatric diseases. The position requires building and mentoring a high‑performing team, coordinating CROs and licensing

Qualifications

• Bachelor's degree in a relevant scientific field.
• PhD preferred.
• Ten-plus years of leadership in drug discovery or related field.

Responsibilities

• Direct the Chemical Induced Proximity Center within the Department of Chemical Biology and Therapeutics.
• Lead strategic decisions across small molecule drug discovery programs; manage cross-functional teams and external partners.
• Drive SAR optimization, ADMET/DMPK collaboration, and publication initiatives in high-impact journals.

Education

Bachelor's degree

PhD

Job description

St. Jude Children's Research Hospital seeks a Principal Scientist to direct our Chemical Induced Proximity Center within the Department of Chemical Biology and Therapeutics.

The role leads strategic drug discovery programs leveraging PROTACs, molecular glues, and other bifunctional approaches, guiding cross-functional collaborations and ensuring translational impact for pediatric diseases. The position requires building and mentoring a high‑performing team, coordinating CROs and licensing