Senior Scientist - In Vivo CAR-T Vector Engineering

The Fountain Group; Gaithersburg (MD); On-site; USD 69,000 - 83,000; Full time

Job summary

The Fountain Group is seeking a Senior Scientist to advance in vivo CAR-T vector delivery, focusing on lentiviral vector engineering and T cell biology. You will own experimental strategy, drive vector platform innovation, and operate with scientific independence in a collaborative cell-therapy group.

Responsibilities include designing complex vector engineering strategies, leading end-to-end LVV platform work, and applying rigorous QC to deliver GMP-like documentation.

Qualifications

• PhD or MS in Cell Therapy, Virology, Immunology, Bioengineering, or related discipline.
• Extensive hands on CAR-T therapy development experience, ex vivo or in vivo.
• Deep expertise in lentiviral vector engineering, production, and QC.
• Advanced knowledge of primary T cell biology and functional assay development.
• Hands on proficiency in mammalian cell culture, including cancer cell lines and primary T cells.
• Advanced multicolor flow cytometry with panel design, acquisition, analysis, and interpretation.
• Proven ability to maintain documentation standards and scientific communication.

Responsibilities

• Generate and characterize stable producer cell lines, including clone screening and banking.
• Design and execute vector engineering and validation for in vivo CAR delivery.
• Lead end-to-end LVV platform execution: production, troubleshooting, optimization, QC strategy.
• Own functional assessment strategy for vector potency and transduction.
• Develop and execute flow cytometry-based assays to quantify transduction and CAR T phenotype.
• Ensure GMP-like documentation and data traceability for internal reviews.
• Make independent technical decisions affecting project direction.
• Identify knowledge gaps and propose new approaches or tech improvements.
• Communicate complex findings to cross-functional stakeholders.
• Role focuses on in vivo LVV platform development for CAR-T cells generated in vivo.

Skills

CAR-T therapy

Lentiviral engineering

Primary T cell culture

Mammalian cell culture

Flow cytometry

Scientific documentation

Education

PhD or MS

Job description

The Fountain Group is seeking a Senior Scientist to advance in vivo CAR-T vector delivery, focusing on lentiviral vector engineering and T cell biology. You will own experimental strategy, drive vector platform innovation, and operate with scientific independence in a collaborative cell-therapy group.

Responsibilities include designing complex vector engineering strategies, leading end-to-end LVV platform work, and applying rigorous QC to deliver GMP-like documentation.