Senior Scientist – Immunology and biotherapeutics

Scorpion Therapeutics; Cambridge (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Scorpion Therapeutics in Cambridge, MA, is seeking a Senior Scientist to lead immunology studies evaluating biotherapeutic modalities, including antibody-oligonucleotide conjugates (AOCs) and xRNA approaches, with a focus on immune profiling and immunogenicity assessment.

You will design and execute complex immune assays using primary cells, analyze immune cell activation and cytokine release, generate mechanistic data for candidate optimization, biomarker development, and safety evaluation, and

Qualifications

• PhD or MSc in Life Sciences with relevant experience in human immunology or cell biology.
• Experience in immune assay development and use of primary immune cells.
• Proficiency in flow cytometry, qPCR, and transcriptomics for immune monitoring.

Responsibilities

• Design and execute complex immune assays using primary cells.
• Analyze immune cell activation and cytokine release.
• Generate mechanistic data for candidate optimization, biomarker development, and safety evaluation.
• Collaborate across oligonucleotide biology, bioanalytics, toxicology, and disease biology teams.
• Communicate findings to project teams.

Skills

immune assay development

primary immune cells

flow cytometry

qPCR

transcriptomics

data analysis

experimental design

Education

PhD in Life Sciences

MSc in Life Sciences

Tools

Transcriptomics platforms

Job description

Role

Senior Scientist leading immunology studies to evaluate biotherapeutic modalities, including antibody-oligonucleotide conjugates (AOCs) and xRNA approaches, focusing on immune profiling and immunogenicity assessment.

Responsibilities

design and execute complex immune assays using primary cells, analyze immune cell activation, cytokine release, innate and adaptive responses, generate mechanistic data for candidate optimization, biomarker development, and safety evaluation; collaborate across disciplines such as oligonucleotide biology, bioanalytics, toxicology, and disease biology; communicate findings to project teams.

Requirements

Ph.D. (0-1 year) or MSc in Life Sciences with 2-5 years research experience in human immunology or cell biology; expertise in immune assay development, primary immune cells, flow cytometry, qPCR, transcriptomics, and immune response assessment; strong data analysis and experimental design skills.

Preferred

knowledge of xRNA biotherapeutics, AOCs, or antibody delivery platforms; experience with orthogonal omics data analysis is a plus.

High-Value

focus on immunogenicity and immune pathway interactions of novel biologics, particularly in early discovery or translational stages.

Work setup

on-site in Cambridge, MA, with no relocation support.