Senior Scientist (I/O) In Vitro/Ex Vivo

ModeX Therapeutics Inc.; Weston, Northern (MA, KY); Hybrid; USD 153,000 - 170,000; Full time

Job summary

ModeX Therapeutics, an OPKO Health company, is seeking a senior scientist with strong hands-on Immunology expertise to advance our immunotherapy programs. The role focuses on designing and executing cell-based studies to evaluate novel biologic drug candidates and their mechanisms of action.

You will develop immune cell-based functional assays using human and mouse cells, optimize multicolor flow panels, and collaborate across discovery and translational teams.

Qualifications

• Ph.D. or MS in Immunology or related field with 10+ years of relevant research, including 4+ years in biotech R&D.
• Strong hands-on Immunotherapy and Immunology expertise.
• Experience designing and interpreting functional assays using primary immune cells and multi-parameter flow cytometry.
• Ability to work independently and in fast-paced biotech environments.
• Excellent written and oral communication for cross-functional teams.

Responsibilities

• Lead in vitro/in vitro studies to characterize drug candidates and mechanisms.
• Develop immune cell-based assays using human and mouse cells and co-culture models.
• Design and troubleshoot multicolor flow cytometry panels.
• Analyze data and provide data-driven recommendations to progress programs.
• Collaborate with discovery, translational and project teams.
• Prepare scientific reports and present findings to teams.

Skills

Immunology

Immunotherapy

Scientific communication

Collaboration

Bench science

Education

PhD/MS in Immunology

Tools

Flow cytometry

Multicolor panels

Cytokine assays

Job description

ModeX Therapeutics, an OPKO Health company, is the leading clinical-stage biopharmaceutical company developing unique and proprietary-multispecific therapeutics. Its MSTAR platform unites the power of multiple biologics in a single molecule to create multispecific antibodies that bind four or more targets with unprecedented versatility and potency for complex diseases. Its promising first-in-class immunology pipeline includes candidates against immune diseases, including cancer (both solid and hematologic tumors), immune impairment, as well as several of the world's most pressing viral threats. Its founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. ModeX is based in Weston, Massachusetts. For more information, please visit www.modextx.com .

Job Description

ModeX Therapeutics is seeking a highly skilled and motivated Senior Scientist with strong hands-on experience in Immuno-oncology/Immunology to support the development and progression of novel immune therapies . The successful candidate will design, execute, and interpret cell-based studies using primary immune cells and relevant assay systems to evaluate biologic drug candidates, characterize their mechanism of action, and address biological questions . This is an exciting opportunity for a collaborative scientist who enjoys working at the bench, brings strong biological insight, and wants to contribute to the development of next‑generation therapeutics in a fast-paced, rapidly growing biotech company with a bold vision.

Key Responsibilities:

• Play a key role in the development of new biologic drugs for Immunotherapy and Immunology
• Independently design, execute, analyze, and interpret in vitro/ex vivo studies to characterize drug candidates and their mechanisms of action
• Develop and perform complex immune cell-based functional assays using primary immune cells (human and mouse), tumor cell lines, reporter systems, and co-culture models
• Design, optimize and troubleshoot multicolor flow cytometry panels, including compensation/unmixing, antibody titration and gating strategies
• Analyze experimental data, generate clear conclusions, and provide data-driven recommendations to advance research programs
• Collaborate cross‑functionally with discovery, translational and project teams to ensure data-driven decision‑making and timely progression of programs.
• Contribute to scientific reports, presentations, and project updates, and effectively communicate findings to cross‑functional teams
• Maintain accurate documentation of experimental activities and ensure compliance with applicable laboratory standards and data integrity practices.

Qualifications:

• Ph.D. or M.S. Degree in Immunology, Cancer Biology, Cell biology, Immuno‑oncology, or a related scientific field, with 10+ years of relevant research experience, including at least 4+ years in a biotech or pharmaceutical R&D environment
• Strong, hands‑on expertise in Immunotherapy and Immunology, with the ability to independently evaluate and apply new concepts and immunoassays
• Demonstrated experience designing, executing, and interpreting functional assays using primary immune cells, including multi-parameter flow cytometry, cytokine profiling (ELISA, MSD, Luminex, or equivalent), immune activation, proliferation, and cytotoxicity assays.
• Hands‑on experience with flow cytometry panel design, optimization, and data analysis; spectral flow cytometry experience is desirable
• Proven ability to work independently, prioritize effectively, and drive projects forward in a fast-paced biotech environment
• Excellent written and oral communication skills, including the ability to present complex data clearly to scientific and cross‑functional audiences
• Strong troubleshooting, organization, data analysis, and problem‑solving skills
• Highly collaborative mindset with the ability to contribute ideas, work across teams, and mentor junior team members as needed

ModeX Therapeutics is an Equal Opportunity Employer

Pay Range

The estimated pay range for this job. Disclosing pay information promotes competitive and equitable pay. The actual pay rate will depend on the person's qualifications and experience. $153,000.00 - $170,000.00 / year

Pay Transparency

In order to support the Fair Compensation Strategy by the US Govt., HR Dept., clients are required to adhere to "Pay Transparency Law"; in the impacted states; that have mandated the employers to list the salary ranges in Job advertisements or postings for job opportunities and Job promotions.

ModeX Therapeutics is an Equal Opportunity Employer.