Senior Scientist, High-Throughput Antibody Discovery

Future Ventures; Berkeley (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

Prellis Biologics in Berkeley, CA seeks a Senior Research Associate / Associate Scientist for High-Throughput Antibody Discovery. You will execute state‑of‑the‑art molecular biology, NGS, and end‑to‑end automation pipelines to accelerate antibody discovery, collaborating across teams in a fast‑paced environment.

The role emphasizes hands‑on execution, platform innovation, and cross‑functional teamwork to deliver life‑changing therapeutics. Competitive salary and growth opportunities are offered.

Qualifications

• BS or MS in Molecular Biology, Biochemistry, Genetics, Immunology, or related field with equivalent industry experience: Sr. Research Associate (BS + 3–5 yrs, or MS + 0–2 yrs); Associate Scientist (BS + 5+ yrs, or MS + 2+ yrs).
• Strong molecular biology fundamentals, including PCR, cloning, mutagenesis, plasmid design and generation, and DNA library construction.
• Experience with automated liquid handlers (Biomek, KingFisher, Tecan, or similar), or willingness to become proficient.
• Hands‑on experience with sample‑to‑data NGS workflows on Illumina platforms (NextSeq, MiSeq, NovaSeq, or similar), including single‑cell technologies (10x Genomics, CITE‑Seq, microfluidic droplets) or comparable techniques.

Responsibilities

• Execute high‑throughput molecular biology workflows, including plasmid generation, PCR, cloning, mutagenesis, and DNA library construction, to support antibody discovery.
• Build and run end‑to‑end automation pipelines on liquid handlers to scale throughput across molecular biology and genomics workflows.
• Execute high‑throughput workflows to probe immune repertoires from diverse discovery sources with single‑cell VH‑VL molecular recovery, NGS, and single‑cell technologies.
• Contribute to technology innovation, troubleshooting, and continuous improvement of our NGS and molecular discovery platforms.
• Apply antibody repertoire bioinformatics tools to evaluate selection outputs; collaborate with Data Science on data visualization and reporting.
• Maintain accurate ELN documentation and communicate results clearly across teams.
• Interface with external vendors and CROs to support antibody discovery workflows.
• Support cross‑functional collaboration across therapeutic programs and technology initiatives.

Skills

Molecular biology

NGS workflows

Automation

Single-cell sequencing

DNA library construction

PCR & cloning

Bioinformatics collaboration

Team collaboration

Documentation

Communication

Education

BS in Molecular Biology/related field

MS in Molecular Biology/related field

Tools

Biomek

KingFisher

Tecan

Illumina NGS

10x Genomics

Job description

Prellis Biologics in Berkeley, CA seeks a Senior Research Associate / Associate Scientist for High-Throughput Antibody Discovery. You will execute state‑of‑the‑art molecular biology, NGS, and end‑to‑end automation pipelines to accelerate antibody discovery, collaborating across teams in a fast‑paced environment.

The role emphasizes hands‑on execution, platform innovation, and cross‑functional teamwork to deliver life‑changing therapeutics. Competitive salary and growth opportunities are offered.