Senior Scientist, High-Throughput Antibody Discovery

Prellis Biologics, Inc; Berkeley (CA); Hybrid; USD 140,000 - 180,000; Full time

Job summary

Prellis Biologics is seeking a Principal Associate Scientist / Scientist for the High Throughput Discovery group in Berkeley, CA. You will apply end‑to‑end primary screening using ELISA and cell‑based assays to identify lead antibody candidates from immunization campaigns.

The role involves scalable HTS workflows, collaboration with Antibody Protein Engineering, Discovery, Production, and Data Science/AI/ML teams, and rigorous data quality control in a fast‑moving environment.

Qualifications

• Hands‑on experience developing primary screens using ELISA and cell‑based assays (iQue).
• Experience isolating/enriching B cells or plasma cells and operating a FACS sorter.
• Proficiency in cloning, PCR, mammalian cell culture, and transient transfection.

Responsibilities

• Isolate and enrich B cells and plasma cells from immunization campaigns; identify antigen‑specific B cells.
• Develop, execute, and optimize primary screens (ELISA and cell‑based assays) in mammalian cells.
• Scale high‑throughput screening strategies for antibody discovery.
• Evaluate emerging technologies to enhance discovery capabilities.
• Develop automated workflows to ensure data quality and reproducibility.
• Collaborate with cross‑functional teams to analyze screening data.
• Manage multiple projects and deliver high‑quality results on schedule.
• Maintain accurate ELN documentation and communicate results clearly.

Skills

Primary cell screening

FACS operation

Mammalian cell culture

Molecular biology (cloning, PCR)

Data analysis (GraphPad Prism, Excel)

Python/R familiarity

Scientific communication

Team collaboration

Education

BSc/MSc in related field

PhD in Immunology/related field

Tools

10x Genomics

microfluidics

iQue

Sony MA900

Job description

Prellis Biologics is seeking a Principal Associate Scientist / Scientist for the High Throughput Discovery group in Berkeley, CA. You will apply end‑to‑end primary screening using ELISA and cell‑based assays to identify lead antibody candidates from immunization campaigns.

The role involves scalable HTS workflows, collaboration with Antibody Protein Engineering, Discovery, Production, and Data Science/AI/ML teams, and rigorous data quality control in a fast‑moving environment.