Senior Scientist, Developability [Contract]

BigHat; San Mateo (CA); On-site; USD 130,000 - 170,000; Part time

Job summary

BigHat Biosciences is seeking a hands-on Senior Scientist, Developability for a 12-month contract in San Mateo, CA. The role emphasizes bench-level work performing IND-enabling developability assessments on late-stage drug candidates from our Milliner Platform.

Expect to spend most time at the bench conducting stability studies and data interpretation. The candidate will lead analytical method development, work with CROs, and translate complex data into actionable steps while exploring new tools

Qualifications

• PhD in Biochemistry or related field with 5+ years industry experience.
• Experience developing and optimizing sensitive analytical chromatography-based methods.
• Strong background in biophysical and analytical characterization of antibodies and fragments.
• Track record translating complex data into clear actions.

Responsibilities

• Lead, design, and execute developability studies to assess drug compatibility with administration materials.
• Develop sensitive analytical methods for quality and recovery assessment.
• Support late-stage characterization including formulation screening and stress testing.
• Drive developability assessments across programs with data interpretation focus.
• Coordinate with external CROs for testing and analytics.
• Communicate findings and propose next steps across the organization.
• Identify and scope state-of-the-art developability tools and technologies.

Skills

5+ years industry experience

Analytical chromatography methods

Biophysical characterization

Data interpretation

Education

PhD in Biochemistry or related discipline

Tools

qSEC

RP-HPLC

CEX

SEC

HIC

CE-SDS

DLS

DSF

ELISA

LC-MS

Job description

Senior Scientist, Developability [Contract]

Department: Lab Science

Employment Type: Contract / Temp

Location: San Mateo, CA

Description

The role: BigHat Biosciences is looking for a hands-on, bench-driven scientist to perform IND-enabling developability assessments on late stage drug candidates from our Milliner Platform for AI-designed therapeutics. This is a lab-based 12-month contract role, with the possibility but no guarantee of conversion to full-time position. You'll spend the majority of your time at the bench executing complex stability studies.

Key Responsibilities

• Lead, design, and execute in-use dose solution studies to assess drug compatibility with administration materials.
• Develop highly sensitive protein characterization methods (qSEC, RP-HPLC, CEX, particle counting, etc) for assessing drug quality and recovery.
• Support late-stage characterization, including formulation screening, stress testing, and peptide mapping, to rank and advance lead candidates.
• Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization.
• Communicate with and manage external CROs for testing and analytics.
• Interpret and communicate scientific findings, propose next steps, and broadcast clearly across the organization.
• Proactively identify and scope state-of-the-art analytical tools and developability technologies.

Skills Knowledge and Expertise

• PhD in Biochemistry or relevant discipline with 5+ year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered.
• Experience developing and optimizing sensitive analytical chromatography-based methods is a must.
• Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS.
• Track record of translating complex data into clear results and recommended actions.
• Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost.