Scientist II, Protein Characterization & Antibody Developability

SRT Therapeutics Inc.; San Diego (CA); On-site; USD 130,000 - 180,000; Full time

Job summary

SRT Therapeutics Inc. is a fast-paced, science-driven biopharma company focused on advancing innovative biologics.

We are seeking a highly motivated Scientist II to lead protein characterization and antibody developability efforts within our Protein Sciences team. The successful candidate will serve as a subject matter expert in analytical and biophysical profiling of diverse therapeutic formats, responsible for hands-on characterization of molecule purity and stability, and for de-risking and

Qualifications

• PhD in Biochemistry, Biophysics, Analytical Chemistry, or a related field.
• Minimum of 3–5 years post-PhD experience in protein & antibody characterization.

Responsibilities

• Design and lead biophysical and analytical characterization of proteins and biologics (SEC-HPLC, HIC, RP-HPLC, CE-SDS, cIEF).
• Independently develop and optimize analytical methods for multispecific platforms.
• Lead discovery project teams as Protein Sciences lead with data interpretation and go/no-go recommendations for lead candidates.
• Troubleshoot instrumentation and anomalous assay results, implementing robust solutions to maintain data quality.
• Document results in electronic lab notebooks and contribute to regulatory filings (IND-enabling data).

Skills

Antibody developability

Biophysical characterization

Experimental design

Data interpretation

Scientific communication

Education

PhD in Biochemistry/Biophysics/Analytical Chemistry or related field

Tools

HPLC/UPLC

Capillary electrophoresis

Job description

SRT Therapeutics is a fast-paced, science-driven biopharma company focused on advancing innovative biologics. We are seeking a highly motivated and independent Scientist II to lead protein characterization and antibody developability efforts within our Protein Sciences team. This role is central to our early-stage discovery and development programs, requiring a strategic thinker who can translate complex biophysical data into actionable insights for therapeutic candidate selection.

About the Job

The successful candidate will serve as a subject matter expert in the analytical and biophysical profiling of diverse therapeutic formats (e.g., mAbs, multispecifics, and ADCs). You will be responsible for hands-on characterization of molecule purity and stability, review of comprehensive developability assessments, troubleshooting complex technical challenges, and driving the analytical strategy to de-risk and accelerate our biologics pipeline.

Key Responsibilities

• Strategic Characterization: Design and lead the biophysical and analytical characterization of proteins and biologics, utilizing techniques including SEC-HPLC, HIC, RP-HPLC, CE-SDS, and cIEF
• Advanced Method Development: Independently develop and optimize product specific analytical methods to support the unique requirements of next-generation multispecific platforms
• Cross-Functional Leadership: Act as the Protein Sciences lead in discovery project teams, providing expert data interpretation and making "go/no-go" recommendations for lead candidates
• Technical Troubleshooting: Serve as the primary technical lead for troubleshooting instrumentation and anomalous assay results, implementing robust solutions to maintain high data quality
• Documentation & Reporting: Maintain rigorous electronic lab notebooks and author high-quality technical reports, SOPs, and regulatory filing contributions (e.g., IND-enabling data)

Qualifications

Education & Experience

• Ph.D. in Biochemistry, Biophysics, Analytical Chemistry, or a related field
• Minimum of 3-5 years of post-PhD experience in a biotech or pharmaceutical setting, specifically focused on protein and antibody characterization

Required Skills

• Subject Matter Expertise: Deep understanding of antibody structure-function relationships and the biophysical drivers of protein stability and manufacturability
• Experimental Design: Proven ability to work independently to design complex experiments, analyze multi-dimensional datasets, and derive meaningful conclusions. The scientist must be adaptable and successfully balance scientific rigor with speed.
• Instrumentation Proficiency: Expert-level hands-on experience with HPLC/UPLC based protein characterization platforms and capillary electrophoresis systems
• Autonomy: Demonstrated track record of managing multiple projects simultaneously in a fast-paced, "startup-style" environment with minimal supervision.
• Communication: Exceptional verbal and written communication skills, with the ability to present complex scientific findings to diverse internal and external stakeholders

Preferred Skills

• Experience with diverse biologics formats such as bispecifics, ADCs, fusion proteins or masked antibodies
• Knowledge of computational tools for predicting protein developability in silico and microscale methods for early therapeutic characterization
• Understanding of developability filters to assess thermal stability, solubility, aggregation propensity, and physical and chemical stress stability