Scientist - Platform & Screening Sciences

Sci.bio Recruiting; Cambridge (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

Sci.bio Recruiting seeks a Scientist or Senior Scientist for an innovative early-stage biotechnology client in Massachusetts. You will advance a proprietary drug-discovery platform through assay development, high-throughput screening, and hit validation.

The role offers collaboration across discovery teams, rigorous data quality, and opportunities to drive progress in therapeutic development in a fast-paced biotech environment.

Qualifications

• 6+ years of industry experience in a lab-based science.
• Hands-on experience developing biochemical assays (TR-FRET, AlphaLISA).
• Experience with SPR/BLI for hit validation.
• Background in high-throughput screening and early drug discovery.
• Cell-based assay development or DEL screening a plus.

Responsibilities

• Develop expertise with the company's discovery platform for target screening.
• Design, optimize, and execute biochemical/biophysical assays for hit identification and validation.
• Collaborate with cross-functional teams to improve workflows and data quality.
• Analyze and communicate experimental results to support decision-making.
• Manage experimental data and documentation; contribute to data integration and reporting.
• Provide scientific oversight for assay development with external CROs.
• Present findings to project teams and senior leadership.
• Contribute to a collaborative, fast-paced research environment focused on innovation.

Skills

TR-FRET

AlphaLISA

SPR/BLI

HTS

DEL screening

PCR/qPCR

Western blot

Gel electrophoresis

Assay development

Data analysis

Scientific communication

CRO management

Biochemistry

Education

PhD in biochemistry/biophysics/molecular biology or related field

BS/MS in a laboratory-based scientific discipline

Job description

Our client, an innovative early-stage biotechnology company, is seeking a Scientist or Senior Scientist to join its Platform & Screening Sciences team. This individual will play a key role in advancing a proprietary drug discovery platform through assay development, high-throughput screening, and hit validation. The position offers the opportunity to work in a highly collaborative environment where scientific contributions will directly impact the discovery and advancement of novel therapeutics.

Responsibilities

• Develop expertise with the company's proprietary discovery platform and apply it to therapeutic target screening.
• Design, optimize, and execute biochemical and biophysical assays to support hit identification, validation, and mechanism of action studies.
• Collaborate with cross-functional teams to improve platform workflows, throughput, reproducibility, and data quality across discovery programs.
• Analyze, interpret, and communicate experimental results to support rapid project progression and scientific decision-making.
• Manage experimental data, maintain accurate documentation, and contribute to efficient data integration and reporting.
• Partner with external CROs by providing scientific oversight for assay development, execution, and quality control.
• Present scientific findings and recommendations to project teams and senior leadership.
• Contribute to a collaborative, fast-paced research environment focused on innovation and continuous improvement.

Required Skills

• BS/MS in a laboratory-based scientific discipline with 6+ years of industry experience, or a PhD in biochemistry, biophysics, molecular biology, or a related field with 3+ years of industry experience.
• Hands-on experience developing and optimizing biochemical assays, including techniques such as TR-FRET and AlphaLISA.
• Experience with biophysical assays, including SPR and/or BLI, for hit validation and characterization.
• Background supporting high-throughput screening and early-stage drug discovery programs.
• Experience with cell-based assay development and/or DNA-Encoded Library (DEL) screening is a plus.
• Working knowledge of molecular biology and biochemistry techniques, including PCR, qPCR, Western blotting, and gel electrophoresis.
• Strong experimental design, data analysis, documentation, and scientific communication skills.
• Ability to independently manage priorities while contributing effectively within cross-functional teams.
• Experience managing or collaborating with CROs is preferred.
• Comfortable working in a dynamic, fast-paced biotech environment with evolving priorities.