Senior Scientist, Clinical Biomarkers – Oncology

Parabilis Medicines; Cambridge (MA); On-site; USD 140,000 - 165,000; Full time

Job summary

Parabilis Medicines in Cambridge, MA seeks a Senior Scientist, Clinical Biomarkers to translate preclinical biomarker findings into clinically feasible strategies for oncology programs. You will select fit‑for‑purpose assays, drive data‑driven decisions, and collaborate with Data Science, Biology, Clinical Science, and Clinical Operations to inform patient selection and response monitoring.

You will lead biomarker analyses from pre‑IND through Phase 1/2, shaping strategy across the pipeline with

Qualifications

• Ph.D. in Cancer Biology, Immunology, or a closely related field.
• 5+ years of total experience with at least 2+ years of industry experience in biomarker research spanning pre‑IND through Phase 1/2 clinical programs.
• Prior experience in preclinical oncology translational research.
• In‑depth knowledge of fit‑for‑purpose assay technologies and their implementation in clinical studies.
• Direct experience with established and evolving biomarker assay technologies (e.g., spatial omics, multiplex immunoassays, NGS, IHC, flow cytometry, ctDNA/liquid biopsy).
• Experience in clinical spatial omics assay design, execution, and downstream bioinformatics analysis (e.g., cell segmentation, spatial clustering), in collaboration with Data Science, is preferred.
• Proven track record of delivering impactful clinical translational data in close collaboration, preferably in an industry setting.
• Demonstrated ability to interpret complex biomarker datasets and translate findings into clinical/scientific recommendations.
• Excellent written and verbal communication skills; experience presenting to cross‑functional and external audiences.
• Publication record in peer‑reviewed oncology/translational research journals.
• Demonstrated ability to utilize AI tools for day‑to‑day work; baseline proficiency is expected, and advanced or innovative use of AI is a strong plus.

Responsibilities

• Capture key biomarkers identified in preclinical studies and assess their feasibility for clinical translation, from pre‑IND through Phase 1/2 programs.
• Develop or qualify and implement fit‑for‑purpose clinical biomarker assays and vendors, setting expectations for anticipated data readouts, interpretation, and delivery timelines.
• Conduct hypothesis‑driven analysis, interpretation, and presentation of clinical biomarker data in support of clinical decision‑making and external engagement.
• Establish and maintain strong collaborative relationships with Data Science and Biology colleagues to perform exploratory biomarker analysis, and support novel biomarker identification.
• Partner with Clinical Science, Clinical Operations, and Clinical Pharmacology to embed biomarker strategy into protocol design and study execution.
• Track and interpret emerging biomarker literature and competitive landscape to inform biomarker strategy.

Skills

Excellent communication

Publication track record

AI tools proficiency

Cross-functional collaboration

Translational biomarker analysis

Education

Ph.D. in Cancer Biology, Immunology, or a closely related field

Tools

Spatial omics

Multiplex immunoassays

NGS

IHC

Flow cytometry

ctDNA/liquid biopsy

Job description

Parabilis Medicines in Cambridge, MA seeks a Senior Scientist, Clinical Biomarkers to translate preclinical biomarker findings into clinically feasible strategies for oncology programs. You will select fit‑for‑purpose assays, drive data‑driven decisions, and collaborate with Data Science, Biology, Clinical Science, and Clinical Operations to inform patient selection and response monitoring.

You will lead biomarker analyses from pre‑IND through Phase 1/2, shaping strategy across the pipeline with