Senior Scientist, Cell Line Development & Viral Vectors

AstraZeneca; Gaithersburg (MD); On-site; USD 112,000 - 168,000; Full time

Job summary

AstraZeneca in Gaithersburg, MD is seeking scientists to advance cell therapy programs. The role centers on single-cell isolation, small-scale viral packaging, high-throughput screening, and evaluating clone productivity to deliver stable, high-performing cell lines.

Collaborate with Process Development and Analytics teams, applying flow cytometry and molecular assays to link clone choices to product quality. PhD or Master in life sciences preferred; CRISPR/Cas9 experience is advantageous.

Qualifications

• PhD or Master's in relevant life sciences required.
• Experience with mammalian CLD and viral vector packaging.
• Experience in single-cell isolation and flow cytometry.
• Strong data analysis and meticulous documentation in a fast-paced lab.

Responsibilities

• Cell Line Development & Viral Packaging: generate single cells/mini-pools and small-scale viral packaging to achieve robust productivity.
• High-Throughput Screening & Analytics Interface: develop scalable workflows for rapid cell characterization and clone evaluation with analytics.
• Cell line engineering: lead improvements to vector quality, stability and performance.
• Data Analysis & Collaboration: interpret datasets and support handoffs with upstream PD and Analytical teams.

Skills

Mammalian CLD

Viral packaging

HEK293 culture

Flow cytometry

High-throughput screening

CRISPR/Cas9

Clone screening

Cell line engineering

Education

PhD or MS in life sciences

Tools

Cell sorter

Imaging systems

Automated liquid handling

Job description

AstraZeneca in Gaithersburg, MD is seeking scientists to advance cell therapy programs. The role centers on single-cell isolation, small-scale viral packaging, high-throughput screening, and evaluating clone productivity to deliver stable, high-performing cell lines.

Collaborate with Process Development and Analytics teams, applying flow cytometry and molecular assays to link clone choices to product quality. PhD or Master in life sciences preferred; CRISPR/Cas9 experience is advantageous.