Early Bioprocess Scientist — Vaccine Development

AstraZeneca GmbH; Seattle (WA); On-site; USD 92,000 - 115,000; Full time

Job summary

AstraZeneca GmbH in Seattle seeks a Scientist, Early Bioprocess Research to advance preclinical vaccine programs through bench-scale development and purification. You will design studies, implement analytical assays, and document findings for regulatory readiness.

The role emphasizes collaboration in a matrix team, strong communication, and troubleshooting across BLI, SEC-MALS, HPLC, DSF, and AKTA systems. Flexibility and in-lab focus are valued.

Qualifications

• Bachelor's or master's degree in Biochemistry, Bioengineering, Molecular Biology or related field with 4+ years of experience.
• Knowledge of protein analytical characterization techniques including BLI, SEC, DLS, HPLC, DSF.
• Recombinant protein expression (mammalian and/or bacterial) is preferred.
• Practical knowledge of recombinant protein purification using AKTA systems is preferred.
• Demonstrated ability to utilize AI-based tools in support of development projects is preferred.
• Strong verbal and written communication and organizational skills.
• Demonstrated troubleshooting ability and multi-tasking capabilities.
• Ability to work collaboratively with direction from project scientists.

Responsibilities

• Collaboratively designs and executes studies for screening and optimization of preclinical vaccine candidates and advances them through lab-scale purification, characterization, formulation, and stability testing.
• Troubleshoots issues with processes, methods and/or results.
• Designs, develops and implements analytical assays (BLI,SEC-MALS, DLS,DSF,HPLC, UHPLC).
• Documents detailed findings in reports and memos to support regulatory submissions and tech transfer to clinical teams.
• Executes activities within a matrix team.
• Communicates experimental findings in written and oral format to project teams.
• Makes observations, interprets data and compiles results and recommendations into reports and presentations.
• Maintains complete and accurate laboratory notebooks.
• Collaborates with internal teams and external vendors on development projects.
• Operates and oversees maintenance of lab instruments.

Skills

Biochemistry

Protein analytics

Mammalian expression

Bacterial expression

Purification with AKTA

AI tools in R&D

Documentation skills

Education

Bachelor's or Master's in Biochemistry/related field

Tools

AKTA systems

Job description

AstraZeneca GmbH in Seattle seeks a Scientist, Early Bioprocess Research to advance preclinical vaccine programs through bench-scale development and purification. You will design studies, implement analytical assays, and document findings for regulatory readiness.

The role emphasizes collaboration in a matrix team, strong communication, and troubleshooting across BLI, SEC-MALS, HPLC, DSF, and AKTA systems. Flexibility and in-lab focus are valued.