Senior Scientist, Biology - Preclinical & Flow Cytometry

Flagship Pioneering; Cambridge (MA); On-site; USD 126,000 - 160,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

FL106 Inc. is seeking a Senior Scientist to join its preclinical research team and lead cell isolation, flow cytometry, and in vivo mouse studies. The role focuses on siRNA-based target validation, imaging, and mechanism discovery to advance therapeutic programs.

The candidate will mentor junior scientists, manage collaborations, and help shape scientific strategy while delivering rigorous, reproducible results in a fast-paced environment.

Qualifications

• Ph.D. in Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Biomedical Sciences, or a related field with 6+ years of relevant experience for Senior Scientist roles; 8+ years for Principal Scientist roles.

Responsibilities

• Design, execute, and analyze complex in vitro and in vivo experiments to support discovery and preclinical programs.
• Lead multi-parameter flow cytometry assays, including panel design, optimization, and data interpretation.
• Perform cell isolation and sorting from various tissues; execute in vivo mouse studies; develop siRNA-based validation and mechanistic studies.
• Design and perform microscopy-based experiments (fluorescence, confocal, live-cell, high-content) and analyze imaging data.
• Collaborate across internal teams and CROs; mentor junior scientists and contribute to strategy and program advancement.

Skills

Flow cytometry

Cell isolation & sorting

In vivo mouse studies

siRNA design & validation

Microscopy

Data analysis & statistics

Scientific communication

Education

Ph.D. in Cell Biology or related field

6+ years of relevant industry experience (Senior Scientist)

Tools

FlowJo

MACS

qPCR

Image analysis (ImageJ/Fiji, Imaris)

RNA-Seq analysis

Job description

FL106 Inc. is seeking a Senior Scientist to join its preclinical research team and lead cell isolation, flow cytometry, and in vivo mouse studies. The role focuses on siRNA-based target validation, imaging, and mechanism discovery to advance therapeutic programs.

The candidate will mentor junior scientists, manage collaborations, and help shape scientific strategy while delivering rigorous, reproducible results in a fast-paced environment.