Senior RNA-LNP Formulation & Process Development Scientist

Eli Lilly and Company; Boston (MA); On-site; USD 72,000 - 189,000; Full time

Job summary

Lilly is seeking a highly skilled scientist to design and execute RNA-LNP formulation and process development studies, supporting early-phase clinical trial supplies and technology transfer. You will work with Discovery, API Development, Analytical Development, and Manufacturing teams to drive platform innovation.

The role requires hands-on experience formulating RNA-LNPs and interpreting analytical data, with strong communication and collaboration skills in a regulated environment.

Qualifications

• Bachelor’s degree in chemical engineering, chemistry, pharmaceutical science, biomedical engineering, or a related field with 4+ years of relevant industry experience.
• Master’s degree in chemical engineering, chemistry, pharmaceutical science, biomedical engineering, or a related field.
• Hands-on experience formulating RNA-LNPs (e.g., mRNA, siRNA, or other nucleic acid payloads), including LNP preparation by rapid mixing and downstream processing (e.g., TFF, dialysis, sterile filtration).
• Hands-on experience with RNA-LNP analytical methods and with interpreting the resulting data.

Responsibilities

• Plan, design, and execute experiments with increasing independence; manage multiple priorities and collaborate across CMC functions and the discovery-development interface.
• Develop and scale LNP manufacturing processes, including rapid-mixing nanoprecipitation, buffer exchange, conjugation, TFF, and sterile filtration.
• Characterize relationships between process parameters and LNP quality attributes using DOE and statistics.
• Perform RNA-LNP characterization using methods such as DLS, RiboGreen assays, UPLC/HPLC lipid analysis, and RNA integrity.

Skills

Experimental design

Data analysis

Communication skills

Cross-functional collaboration

Education

Bachelor's degree in chemical engineering/chemistry/pharmaceutical science/biomedical engineering

Master's degree in chemical engineering/chemistry/pharmaceutical science/biomedical engineering

Experience formulating RNA-LNPs

RNA-LNP analytical methods experience

Tools

DLS

RiboGreen assays

UPLC/HPLC lipid analysis

Gel electrophoresis

Job description

Lilly is seeking a highly skilled scientist to design and execute RNA-LNP formulation and process development studies, supporting early-phase clinical trial supplies and technology transfer. You will work with Discovery, API Development, Analytical Development, and Manufacturing teams to drive platform innovation.

The role requires hands-on experience formulating RNA-LNPs and interpreting analytical data, with strong communication and collaboration skills in a regulated environment.