Senior Research Lab Tech, Mass Spectrometry

Jobtailor; Cambridge (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

Jobtailor in Cambridge, MA seeks a proteomics-focused scientist to run and maintain the mass spectrometry platform, executing workflows across human tissue processing, immunofluorescence imaging, and laser microdissection. You will generate high-quality data on Orbitrap Astral and collaborate with postdoctoral and computational colleagues.

The role involves developing protocols, interpreting results, and contributing to manuscripts while maintaining SOPs and reporting progress regularly.

Qualifications

• Bachelor's Degree in Biochemistry, Analytical Chemistry, Molecular Biology, or related field.

Responsibilities

• Run and maintain the laboratory's mass spectrometry platform.

Skills

LC-MS experience

Orbitrap Astral operation

Protein extraction

Statistics analysis

Education

Bachelor's Degree in Biochemistry/Analytical Chemistry/Molecular Biology

Tools

Orbitrap Astral

Vanquish Neo

Evosep One

Database Management Software

Job description

• Run and maintain the laboratory's mass spectrometry platform
• Execute workflows spanning human tissue processing, immunofluorescence imaging, laser microdissection, low-input proteomic sample preparation, and ultra-sensitive mass spectrometry
• Generate high-quality proteomic data on the Orbitrap Astral
• Work closely with postdoctoral and computational colleagues
• Help establish core methods and operational standards
• Develop or contribute to modifications of assay techniques, experimental protocols, and new procedures
• Synthesize and interpret results
• Prepare written and/or verbal status reports
• Perform statistical analysis and make recommendations
• Independently perform non-routine, highly specialized experimental procedures
• Compose and potentially present sections of research reports and manuscripts

Requirements

• Bachelor's Degree in a related field required (Biochemistry, Analytical Chemistry, Molecular Biology, or a related field)
• 3–5 years of experience in an academic or laboratory research setting required
• Minimum of 3 years of hands-on LC-MS experience required
• Hands-on operation, routine maintenance, and systematic troubleshooting of complex LC-MS setups for high-throughput quantitative proteomics
• Prior experience with nanoflow workflows and the Orbitrap Astral, Vanquish Neo, and Evosep One highly desirable
• Expertise in protein extraction and enzymatic digestion
• Experience with low-input workflows and PTM enrichments such as phosphoproteomics ideally
• Experience optimizing and troubleshooting protocols and MS acquisition methods
• Experience documenting rigorous laboratory SOPs
• Practical experience with human tissue sectioning, including cryosectioning and FFPE, immunofluorescence staining, or laser microdissection is a strong advantage
• Excellent communication skills
• Good interpersonal skills and ability to oversee the work of others
• Ability to work independently
• Ability to identify problems and develop solutions
• Ability to prioritize tasks and set deadlines
• Strong database management and overall computer skills
• Ability to function with speed, precision, and understanding of the theory behind tests and procedures

Core Competencies

Demonstrates expertise in mass spectrometry, particularly with LC-MS and the Orbitrap Astral, while effectively synthesizing and interpreting proteomic data. Capable of developing and optimizing experimental protocols and maintaining rigorous laboratory standards.

Highest-signal resume keywords

• LC-MS Experience
• Orbitrap Astral Operation
• Protein Extraction Expertise
• Statistical Analysis Skills
• Laboratory SOP Documentation

ATS Optimization Keywords

Hard Skills

• Mass Spectrometry
• Proteomic Sample Preparation
• Human Tissue Processing
• Immunofluorescence Imaging
• Laser Microdissection
• Statistical Analysis
• Assay Technique Development
• Experimental Protocol Modification
• Low-Input Workflows
• PTM Enrichment

Soft Skills

• Excellent Communication Skills
• Interpersonal Skills
• Problem-Solving Ability
• Independence
• Task Prioritization

Industry Keywords

• Biochemistry
• Analytical Chemistry
• Molecular Biology
• Laboratory Research
• High-Throughput Quantitative Proteomics

Tools & Technologies

• Orbitrap Astral
• Vanquish Neo
• Evosep One
• Database Management Software