Project Chemist (Mass Spectrometry)

Eagle; Houston (TX); On-site; USD 60,000 - 90,000; Full time

Job summary

Eagle is seeking a Project Chemist to support routine LC-MS–based analysis in a fast-paced laboratory. The role includes sample preparation, instrument operation, troubleshooting, and data review to ensure timely, high-quality analytical results.

The candidate will work with LC-MS/MS and HPLC/UHPLC systems, perform method validation activities as needed, and collaborate with cross-functional teams to meet project timelines in a GMP-aligned environment.

Qualifications

• Bachelor’s or Master’s degree in chemistry, analytical chemistry, biochemistry, or related field.
• Hands-on experience with LC-MS/MS instrumentation and workflows.
• Experience with mass spectrometry–based protein and peptide characterization, including sample prep, instrument operation, and data analysis, preferred.
• Experience with LC-MS/MS quantitation using MRM and/or SIR acquisition modes preferred.
• Hands-on experience with HPLC or UHPLC systems.
• Familiarity with biological and/or chemical sample matrices.
• Experience with basic wet chemistry and sample preparation techniques.
• Familiarity with GMP (Good Manufacturing Practices) and applicable regulatory requirements (e.g., FDA, ICH)
• Strong attention to detail, organizational skills, and documentation practices.
• Comfortable working with laboratory software and data management systems.
• Ability to work independently as well as collaboratively in a team environment.
• Strong verbal and written communication skills.

Responsibilities

• Perform routine LC-MS based assays including peptide mapping, intact mass analysis and protein/small molecule quantitation in a timely and compliant manner.
• Prepare samples, standards, mobile phases, buffers, and other laboratory solutions.
• Operate and maintain LC-MS/MS and HPLC/UHPLC systems following SOPs.
• Conduct routine analytical runs and monitor instrument performance.
• Review, organize, interpret, and document analytical data and laboratory records.
• Identify and report unexpected test results, providing initial troubleshooting where applicable.
• Perform system suitability, calibration, and QC checks.
• Troubleshoot basic instrument and method issues.
• Maintain laboratory cleanliness, inventory, and organization.
• Support method optimization and validation activities as appropriate.
• Collaborate with cross-functional team members to support project timelines and deliverables.

Skills

LC-MS/MS workflows

Data review & interpretation

Independent & collaborative work

Documentation practices

Attention to detail

Education

Bachelor’s or Master’s in Chemistry/Analytical Chemistry/Biochemistry

Tools

LC-MS/MS instrumentation

HPLC/UHPLC systems

Job description

We are seeking a motivated Project Chemist to support routine LC-MS–based analysis in a fast-paced laboratory environment. This role is responsible for the timely and reliable execution of LC-MS/MS workflows, including sample preparation, instrument operation, troubleshooting, and data review. The ideal candidate is comfortable working with minimal supervision, maintaining instrument performance, and delivering high-quality analytical results in a timely manner.

What You Will Do

• Perform routine LC-MS based assays including peptide mapping, intact mass analysis and protein/small molecule quantitation in a timely and compliant manner
• Prepare samples, standards, mobile phases, buffers, and other laboratory solutions
• Operate and maintain LC-MS/MS and HPLC/UHPLC systems following SOPs
• Conduct routine analytical runs and monitor instrument performance
• Review, organize, interpret, and document analytical data and laboratory records
• Identify and report unexpected test results, providing initial troubleshooting where applicable.
• Perform system suitability, calibration, and QC checks
• Troubleshoot basic instrument and method issues
• Maintain laboratory cleanliness, inventory, and organization
• Support method optimization and validation activities as appropriate
• Collaborate with cross-functional team members to support project timelines and deliverables

Who You Are

• Bachelor’s or Master’s degree in chemistry, Analytical Chemistry, Biochemistry, or related field
• Hands‑on experience with LC-MS/MS instrumentation and workflows
• Experience with mass spectrometry–based protein and peptide characterization, including sample preparation, instrument operation, and data analysis, preferred
• Experience with LC-MS/MS quantitation using MRM and/or SIR acquisition modes preferred
• Hands‑on experience with HPLC or UHPLC systems
• Familiarity with biological and/or chemical sample matrices
• Experience with basic wet chemistry and sample preparation techniques
• Familiarity with GMP (Good Manufacturing Practices) and applicable regulatory requirements (e.g., FDA, ICH)
• Strong attention to detail, organizational skills, and documentation practices
• Comfortable working with laboratory software and data management systems
• Ability to work independently as well as collaboratively in a team environment
• Strong verbal and written communication skills

Preferred Experience

• Hands‑on experience with HPLC, UPLC, and MS instrumentation.
• Knowledge of peptide synthesis and purification techniques.
• Experience in a pharmaceutical or biotechnology setting.
• Understanding of protein chemistry and post‑translational modifications.

Who We Are

Serving customers since 2004, Eagle offers the highest quality in preparation testing for sterility, bacterial endotoxins, microbial detection, beyond-use dating (BUD) determination and active ingredient potency. State‑of‑the‑art equipment, combined with the experience and knowledge of our team, makes Eagle the best choice for all testing needs. The Eagle team is committed not only to performing the best quality control testing but also working relentlessly with our customers on solutions if tests receive unexpected results. Learn more at www.eagleanalytical.com.