Senior Scientist UVA BAF Core

University of Virginia; Charlottesville (VA); On-site; USD 110,000 - 150,000; Full time

Job summary

The W.M. Keck Biomedical Mass Spectrometry Lab at the University of Virginia seeks a Senior Scientist to expand proteomics and metabolomics efforts using state-of-the-art instruments to support research across basic science, Cancer Center, and clinical projects.

The role requires expert hands-on biomedical science experience with MS and chromatography, and data analysis using Proteome Discoverer, Scaffold, and related software.

Qualifications

• Possess prior experience in qualitative and quantitative proteomics and metabolomics technology and nano‑liquid chromatography and mass spectrometry (LC‑MS; on Orbitrap Fusion, Orbitrap Astral, and/or Orbitrap ID‑X).
• The candidate should be familiar with the entire metabolomics and/or proteomics pipeline (including sample preparation, LC and MS operation, and data analysis) and must be able to conduct independent projects.
• Manage multiple projects between multiple laboratories.
• Demonstrate scientific productivity and have excellent oral and written communication skills.
• Demonstrate attention to detail and ability to learn new technologies, flexibility and time management skills.

Responsibilities

• Operate and maintain advanced mass spectrometers (Orbitrap ID‑X – Vanquish Neo and Orbitrap Astral Zoom – Evosep Eno).
• Support the director through sample preparation and data analysis using advanced software packages (Proteome Discoverer, Compound Discoverer, Scaffold, etc).
• Advance institutional goals in proteomic and metabolomic profiling and translational research.
• Collaborate across laboratories and manage multiple projects.

Skills

Proteomics

Metabolomics

Mass spectrometry

Chromatography

Data analysis

Independent projects

Communication skills

Time management

Laboratory management

Education

Ph.D. in Mass Spectrometry

Tools

Proteome Discoverer

Compound Discoverer

Scaffold

MS Dial

MetaboAnalyst

Orbitrap Fusion

Orbitrap Astral

Orbitrap ID-X

Thermo instruments

Job description

Main Duties and Responsibilities

The W.M. Keck Biomedical Mass Spectrometry Lab – a part of the Biomolecular Analysis Facility Core at the University of Virginia – seeks a Senior Scientist to expand our work in the areas of proteomics and metabolomics using state‑of‑the‑art instruments to support research within the institution in areas such as basic science research, the Cancer Center, and clinical projects. This position requires expertise and hands‑on experience in biomedical science. The candidate should have documented expertise in mass spectrometry and chromatography as well as protein and small molecule chemistry. You will support the director through sample preparation, operation/maintenance of advanced mass spectrometers (Orbitrap ID‑X – Vanquish Neo and Orbitrap Astral Zoom – Evosep Eno), and data analysis using advanced software packages (Proteome Discoverer, Compound Discoverer, Scaffold, etc). This work will advance institutional goals in proteomic and metabolomic profiling and translational research.

The ideal candidate will have a proven record of excellent communication and team support. You should be highly motivated and able to work independently when designing and executing experiments. The customer support of researchers within the institution is a high priority. Projects will include use of existing techniques to answer current biological challenges and the development of new technologies in proteomics and metabolomics.

Essential Requirements

• Possess prior experience in qualitative and quantitative proteomics and metabolomics technology and nano‑liquid chromatography and mass spectrometry (LC‑MS; on Orbitrap Fusion, Orbitrap Astral, and/or Orbitrap ID‑X).
• The candidate should be familiar with the entire metabolomics and/or proteomics pipeline (including sample preparation, LC and MS operation, and data analysis) and must be able to conduct independent projects.
• Manage multiple projects between multiple laboratories.
• Demonstrate scientific productivity and have excellent oral and written communication skills.
• Demonstrate attention to detail and ability to learn new technologies, flexibility and time management skills.

Desirable Requirements

• Ph.D. in Mass Spectrometry or in a very closely related field with 5+ years’ direct experience in mass spectrometry or a MS in very closely related field and 10+ years’ experience in proteomics or metabolomics.
• Ability to collaborate across multiple disciplines and engage investigators in project design, execution and data analysis.
• Experience in publication and grant writing.
• Experience with Proteome/Compound Discoverer, Scaffold, MS Dial, MetaboAnalyst, etc.
• Advanced knowledge of Thermo mass spectrometers – operation and maintenance.