Mass Spectrometry Scientist

Parallel Squared Technology Institute; Watertown (MA); On-site; USD 120,000 - 170,000; Full time

Benefits offered by this job

Medical, dental, and vision insurance

PTO and sick leave

Educational reimbursement

Parental leave

Job summary

Parallel Squared Technology Institute (PTI) seeks an experienced Mass Spectrometry Scientist to maintain and operate MS instruments across multiple vendors for diverse proteomics projects. You will run experiments, analyze data, train colleagues, and contribute to hypothesis-driven research while advancing mass spectrometry capabilities and throughput.

Applicants must hold a PhD in Chemistry or Biochemistry and have 5+ years of MS experience, with LC-MS/MS expertise and a strong background in

Qualifications

• PhD in Chemistry, Biochemistry, or related field.
• 5+ years of experience maintaining mass spectrometers.
• Experience optimizing LC-MS/MS methods for bottom-up proteomics.
• Mastery of chemistry techniques or molecular & cellular biology techniques.
• Demonstrated enthusiasm & interest in bioanalytical chemistry.
• High level of initiative and flexibility, excellent communication and teamwork skills.
• Attention to detail and good time management skills.

Responsibilities

• Set up, operate, and maintain mass spectrometers from multiple vendors (Thermo, Bruker, Sciex, etc.).
• Analyze experimental data and interpret results for internal and public presentation.
• Train team members to use instruments independently.
• Design relevant proteomic experiments.
• Perform protein sample preparation.
• Communicate with purchasing and may negotiate with vendors.
• May manage MTAs, software licenses, service contracts, and other documentation.

Skills

Mass spectrometry

LC-MS/MS methods

Chemistry techniques

Bioanalytical chemistry

Communication skills

Time management

Attention to detail

Education

PhD in Chemistry

PhD in Biochemistry

Job description

Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians.

Why?

Protein dysfunctions directly cause many diseases, such as Alzheimer’s disease. Yet, proteins remain understudied because of technological hurdles.

How?

To resolve these limitations, PTI will develop mass tags enabling a new framework for multiplexed protein analysis by mass spectrometry towards achieving 100-fold increase in throughput. Scientists at and collaborating with the institute will use these gains to directly investigate disease mechanisms and resolve problems that have proven intractable for decades. Our proof of principle technology and strategies are outlined at: parallelsq.org.

PTI’s new approach requires synergy between a diverse team of chemists, machine learning engineers, biologists, and mass spectrometrists. Alzheimer’s disease and aging will be among the first focuses of this technology-driven research organization.

New career opportunities

Members of PTI will be supported with industry-level resources to lead research projects and disseminate their discoveries and innovations to the broader biomedical community through frequent publications, presentations, and submissions to public data portals.

Summary of Position

We are looking for an experienced Mass Spectrometry Scientist who will be working on maintaining MS instruments for running multitudes of samples for a variety of projects in addition to other responsibilities such as advancing and executing hypothesis-driven experiments. In order to be seriously considered for this position, we require a cover letter as part of the candidate’s application.

Responsibilities

• You will setup, operate, and maintain (i.e. vent and clean) mass spectrometers from multiple major vendors (Thermo, Bruker, Sciex, etc.).
• Analyze experimental data and interpret results for internal and public presentation.
• Train team members to use instruments independently.
• Design relevant proteomic experiments.
• Perform protein sample preparation.
• Communication with purchasing and may be responsible for negotiating with various vendors.
• May manage MTAs, software licenses, service contracts, and other documentation.

We Offer

• An opportunity to change the world and work with some of the smartest and the most talented experts from different fields.
• Excellent medical, dental, and vision insurance with many $0 premium options for you and your family with several national and regional providers. Most employees have more than 20 plan options to choose from.
• Company-paid group life, AD&D, long- and short-term disability insurance.
• 15 days PTO + 10 sick days per year.
• 18 company holidays + your birthday off.
• $5,000 per year educational reimbursement.
• Up to 16 weeks paid parental leave.
• Industry competitive salary.

We aim to help fill a structural gap in today's R&D system. We enable fundamental research that requires unusual levels of scale and coordination yet is not rapidly monetizable by industry. We’re bringing together top talent from academia, industry, and startups to build a new model for innovative R&D. As an incubator within the Schmidt Futures Network, we identify high-impact scientific or technical research and development opportunities, ultimately defining and launching these projects as Focused Research Organizations.

We are an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.

Required Qualifications

• PhD in Chemistry, Biochemistry, or related field.
• 5+ years of experience maintaining mass spectrometers.
• Demonstrated experience optimizing LC-MS/MS methods for bottom-up proteomics (e.g. DDA/DIA/prioritized approaches).
• Demonstrated mastery of chemistry techniques or molecular & cellular biology techniques.
• Demonstrated enthusiasm & interest in bioanalytical chemistry.
• High level of initiative and flexibility, excellent communication and teamwork skills.
• Attention to detail and good time management skills.

Preferred Qualifications

• Proficiency with statistical and computational methods (e.g. coding in Python/R).
• Proven ability of written and oral scientific communication.