Senior/Research Associate, Single Cell Technology

NewLimit; South San Francisco (CA); On-site; USD 75,000 - 100,000; Full time

Benefits offered by this job

401(k) with company match

Health, dental, and vision insurance

Meals and snacks on-site

Job summary

NewLimit is seeking a Senior/Research Associate with experience in biological sample processing and molecular biology to join our Single Cell Technology and Assay Development group. Our team develops and applies advanced molecular and bioanalytical technologies to support therapeutic discovery, spanning single-cell genomics, biomarker development, biodistribution, and bioanalytical method development.

You will design and execute experiments involving isolation, culture, and processing of cells

Qualifications

• Bachelor's degree in cell biology, molecular biology, or a related natural science or industry experience
• 2+ years of work experience in a cell or molecular biology laboratory (academic or industry)
• Experience with standard molecular biology workflows (e.g., nucleic acid extraction, qPCR, ELISA, NGS library construction, library quantification and QC)
• Experience with necropsy, organ/tissue collection, primary tissue dissociation, mammalian cell culture and sample processing (e.g. single cell suspension preparation, nuclei isolation, fixation)

Responsibilities

• Measure biodistribution, pharmacokinetics & efficacy of reprogramming medicines using traditional molecular assays and frontier genomics methods
• Design and execute experiments involving isolation, culture, and processing of cells, tissues, and organs for molecular profiling
• Collaborate with the Epigenetic Editing team to perform large-scale, single cell perturbation experiments with custom chemistries
• Perform state-of-the-art single cell profiling experiments to map epigenetic features of age-related disease and evaluate interventions

Skills

Cell culture

Molecular biology workflows

qPCR

ELISA

NGS library construction

Nucleic acid extraction

Nuclei isolation

Single cell suspension

Flow cytometry sorting

Education

Bachelor's degree in cell biology or molecular biology

Tools

10x Genomics

Parse Bio

Perturb-seq / CROProp-seq

Job description

Senior/Research Associate, Single Cell Technology

Company info

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description

NewLimit is seeking a Senior/Research Associate with experience in biological sample processing and molecular biology to join our Single Cell Technology and Assay Development group. Our team develops and applies advanced molecular and bioanalytical technologies to support therapeutic discovery and development, spanning single-cell genomics, biomarker development, biodistribution, and bioanalytical method development.
As a member of our team, you will:

• Measure the biodistribution, pharmacokinetics & efficacy of reprogramming medicines using traditional molecular assays as well as frontier genomics methods
• Design and execute experiments involving the isolation, culture, and processing of cells, tissues, and organs for molecular profiling
• Collaborate with our Epigenetic Editing team to perform large-scale, single cell perturbation experiments with custom chemistries
• Perform state-of-the‑art single cell profiling experiments to map epigenetic features of age‑related disease and evaluate interventions

Requirements

• Bachelor’s degree in cell biology, molecular biology, or a related natural science or industry experience
• 2+ years of work experience in a cell or molecular biology laboratory (academic or industry)
• Experience with standard molecular biology workflows (e.g., nucleic acid extraction, qPCR, ELISA, NGS library construction, library quantification and QC)
• Experience with necropsy, organ/tissue collection, primary tissue dissociation, mammalian cell culture and sample processing (e.g. single cell suspension preparation, nuclei isolation, fixation)

Nice to have

• Experience with in vivo animal handling
• Experience with single cell genomics methods (such as 10x Genomics, Parse Bio, Perturb‑seq/CROProp‑seq or similar)
• Experience troubleshooting or optimizing NGS workflows.
• Experience with flow cytometry sorting for single‑cell preparations.
• Health, dental, and vision insurance
• 401(k) with company match
• Industry‑leading paid time off (PTO) -- 20 days/year for all employees + holidays
• Paid parental leave
• Meals and snacks on‑site

Salary Range: $75,000 to $100,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.