Scientist, Metabolism

NewLimit; South San Francisco (CA); On-site; USD 130,000 - 165,000; Full time

Benefits offered by this job

Health, dental, and vision insurance

401(k) with company match

Paid parental leave

Industry-leading PTO — 20 days/year +

Meals on-site

Job summary

NewLimit is a biotechnology company focused on aging and metabolic health. We are seeking a Scientist with liver biology and metabolism expertise to join our Metabolism team.

You will develop assays for hepatocyte function, collaborate across teams, and contribute as an SME to advance therapeutic development for age-related disease. You will work on designing epigenetic reprogramming interventions, evaluating payloads, and delivering perturbations to hepatocytes in vivo, with opportunities to

Qualifications

• Ph.D. in cell biology, molecular biology, biochemistry or related field (or equivalent industry experience).
• Experience with primary liver cell isolation and functional characterization.
• Experience with mouse models of liver dysfunction.
• Experience with transgenic manipulation of liver cells ex vivo or in vivo (e.g. viral vectors, nucleic acid delivery).
• Exceptional organizational skills, including detailed experimental record-keeping and ability to manage multiple concurrent projects.

Responsibilities

• Collaborate with Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes.
• Develop assays to preclinical models of liver disease to measure hepatocyte function.
• Evaluate epigenetic reprogramming payloads using in vivo functional assays to select therapeutic candidates.
• Deliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods.
• Analyze and interpret experimental data to drive pre-clinical decision making.

Job description

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description

NewLimit is seeking an scientist with experience in liver biology and metabolism to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.

As a Scientist on our team, you will:

• Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes
• Develop assays to preclinical models of liver disease to measure hepatocyte function
• Evaluate epigenetic reprogramming payloads using in vivo functional assays to select therapeutic candidates
• Deliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods (e.g. viral vectors, lipid nanoparticles)
• Analyze and interpret experimental data to drive pre-clinical decision making

Requirements

• Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
• Experience with primary liver cell isolation and functional characterization
• Experience working with mouse models of liver dysfunction
• Experience with transgenic manipulation of liver cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)
• Exceptional organizational skills, including detailed experimental record-keeping and the ability to manage multiple concurrent project

Nice to have

• History of contributing to a drug development program at the pre-clinical or clinical development stage
• Experience leading the design and execution of pre-clinical studies in mouse models
• Experience with single cell genomics methods
• Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)

NewLimit offers generous benefits to ensure our team can focus on our mission:

• Health, dental, and vision insurance
• 401(k) with company match
• Paid parental leave
• Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
• Meals and snacks on-site

Salary Range: $130,000 to $165,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Learn more at: https://www.newlimit.com/careers

*This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future