Scientist/Senior Scientist

NewLimit; South San Francisco (CA); On-site; USD 113,000 - 171,000; Full time

Benefits offered by this job

Health, dental, and vision insurance

401(k) with company match

Paid parental leave

20 days/year paid time off

Meals and snacks on-site

Job summary

A biotechnology company in South San Francisco is looking for a Scientist to join their Vascular team. The role involves developing assays to measure the functional decline in endothelial cells and collaborating to create reprogramming medicines to combat age-related diseases. Candidates should have a Ph.D. or equivalent industry experience, with a proven track record in cell biology and functional characterization. This position offers competitive salary and benefits, including healthcare and generous PTO.

Qualifications

• 5+ years of industry experience or a Ph.D. in a relevant field.
• Experience with primary cell isolation and functional characterization.
• Experience working with mouse models of disease.

Responsibilities

• Develop functional assays to measure endothelial cell function.
• Collaborate with teams to test reprogramming hypotheses.
• Analyze experimental data to inform pre-clinical decisions.

Skills

Cell biology

Molecular biology

Biochemistry

Functional characterization

Experimental data analysis

Education

Ph.D. in cell biology, molecular biology, biochemistry, or related field

Tools

Viral vectors

Nucleic acid delivery methods

Job description

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Position

NewLimit is seeking a scientist with experience in discovery biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases.

Your role will focus on developing and deploying assays to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our technology teams to help create the first reprogramming medicines for the vascular tissue that supports all others.

What you\'ll do

In your role as a Scientist, you will:

• Develop functional assays and pre-clinical models to measure endothelial cell function
• Collaborate with our Functional Genomics and Predictive Modeling teams to test reprogramming hypotheses at scale
• Measure the impact of mRNA reprogramming medicines on endothelial cell function
• Engineer in vivo nucleic acid delivery methods for endothelial cells
• Analyze and interpret experimental data to drive pre-clinical decision making

Requirements

• Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
• Experience with primary cell isolation and functional characterization
• Experience working with mouse models (e.g. kidney, cardiovascular, or cognitive disease models)
• Experience with transgenic manipulation of primary cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)

Nice to have

• History of contributing to a drug development program at the pre-clinical or clinical development stage
• Experience leading the design and execution of pre-clinical studies in mouse models
• Experience with single cell genomics methods
• Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)

Benefits

• Health, dental, and vision insurance
• 401(k) with company match
• Paid parental leave
• Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
• Meals and snacks on-site

Salary Range: $113,000 to $171,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company\'s good faith estimate as of the date of publication and may be modified in the future.

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