Research Associate/Sr. Research Associate in vivo pharmacology

Signify Bio; Dallas (TX); On-site; USD 70,000 - 90,000; Full time

Job summary

A pioneering RNA biotechnology company in Dallas seeks a Research Associate/Senior Research Associate to conduct in vivo pharmacology studies. The role involves designing experiments, handling rodents, and ensuring high standards of animal welfare. Ideal candidates will have a BS/MS in Life Sciences, 2-5+ years of in vivo research experience, and proficiency in molecular biology techniques. This position is lab-based, requiring adaptability and strong attention to detail while following strict compliance with health and safety guidelines.

Qualifications

• 2-5+ years of in vivo research experience, ideally in a biopharmaceutical setting.
• Experience with rodent handling and dosing techniques.
• Proficiency in ELISA, Western Blot, and quantitative PCR.

Responsibilities

• Conduct in vivo pharmacology studies in rodent models.
• Collect and process biological samples for analysis.
• Maintain accurate experimental records in electronic lab notebooks.

Skills

In vivo research experience

Molecular biology techniques

Excellent organizational skills

Communication skills

Attention to detail

Education

BS/MS in Life Sciences

Tools

Word

Excel

PowerPoint

GraphPad Prism

Job description

Research Associate/Senior Research Associate in vivo pharmacology

Signify Bio is a pioneering early-stage RNA/LNP biotechnology company harnessing the human body for the production of in situ protein therapeutics. We aim to create personalized medicines for all by combining the promise of signal peptide engineered control with the speed and power of mRNA encoded design. With labs in Dallas, TX, we are building three proprietary and novel platforms encompassing both nucleic acid payloads and non-viral delivery systems designed to control the production, secretion and localization of protein therapeutics directly within the human body.

Role Description

We are adding a Research Associate/Senior Research Associate (non-PhD) to our Translational Sciences team to execute in vivo pharmacology and molecular biology studies. Primary responsibility will be conducting in vivo studies to identify and progress lead formulations towards the clinic. This role involves handling and dosing rodents, collecting samples for downstream biochemical assessments, execution of biochemical assessments, and maintaining accurate records to support PK/PD, efficacy, and safety in vivo and molecular biology studies.

Essential Duties and Responsibilities

• Design and perform in vivo pharmacology studies in rodent models, including dosing (IV, IP, SC, IM) and tissue collection in mice and rats
• Collect and process biological samples (blood, liver, muscle, and other organs) for downstream analysis
• Design, perform and analyze molecular biology experiments, including ELISA, WB, QPCR
• Maintain accurate records of experiments, protocols, and data in electronic lab notebooks (ELN)
• Collaborate daily with cross‑functional teams, including Biology and Formulations
• Ensure compliance with IACUC protocols and maintain high standards of animal welfare

Qualifications

• BS/MS in Life Sciences, including Pharmacology, Immunology, Biology, or a related field with 2‑5+ years of in vivo research experience (industry experience preferred)
• Hands‑on experience with rodent (rat and mouse) handling, dosing techniques, in‑life and terminal blood collection, and necropsy
• Proficiency with i.v., s.c., and i.m. injections and blood collection by various methods
• Proficiency with molecular biology techniques and methods, including ELISA, WB, QPCR
• Proficient in Word, Excel, PowerPoint, and GraphPad Prism
• Highly adaptable and capable of adjusting to shifting priorities
• Able to work in a fast‑paced and highly collaborative environment
• Excellent organizational and communication skills
• Strong attention to detail

Physical Requirements

This lab-based position requires the ability to stand for extended periods as well as occasional need to reach, bend, stoop, and climb stairs. Working with rodent cages may require working in an uncomfortable physical position briefly in order to change or clean cages. Lifting requirement may occasionally be up to approximately 25 lbs. Pushing/pulling carts or cage racks may be required. Manual dexterity and fine motor skills are needed to handle small animals.

Position involves regular exposure to biological materials such as animal allergens and requires regular use of Personal Protective Equipment (gown, mask, gloves) and strict compliance with Environmental Health & Safety guidelines.

Sorry, no relocation assistance or immigration sponsorship is available for this position.

Signify Bio is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.