Senior Research Associate, Oncology NGS & Assay Development

personalisinc; Fremont (CA); Hybrid; USD 85,000 - 115,000; Full time

Benefits offered by this job

Medical benefits

Dental & Vision

401k match

ESPP program

Tuition reimbursement

Paid time off

Commuter benefits

EV charging access

Onsite gym

Wellness program

Job summary

Personalis in Fremont, California is seeking a hands-on molecular biology professional to join a multidisciplinary R&D team. You will operate NGS equipment, perform library preparation from real-world samples, and help develop precision oncology products used by pharma, biotech, and clinical partners.

Responsibilities include assay and workflow execution, DNA/RNA extraction, quality control (Qubit, TapeStation), sample prep for NGS, validation studies, SOP refinement, and meticulous

Qualifications

• BS/MS in Molecular Biology, Genomics, Biochemistry, or a related biological science.
• 3+ years hands-on molecular biology laboratory experience (biotech/pharma preferred).
• Proficiency in DNA/RNA extraction, quality control (e.g., Qubit, TapeStation), and NGS library preparation.

Responsibilities

• Assay & Workflow Execution: Support R&D scientists in developing, optimizing, and validating novel oncology assays and workflows.
• Sample Prep & Library Generation: Extract DNA/RNA from biological samples (blood, tissue) and construct high-quality libraries for Next-Generation Sequencing (NGS).
• Validation & Collaboration Studies: Process sample cohorts for critical assay validation studies and external industry/academic collaborations under tight timelines.
• Protocol Refinement: Evaluate new protocols as a front-line user and provide constructive feedback to optimize SOPs.
• Documentation & Reporting: Maintain meticulous sample tracking and experimental records in lab notebooks; present findings in team meetings.
• Compliance: Maintain compliance with safety guidelines, quality standards, and company policies.

Skills

NGS library preparation

DNA/RNA extraction

Quality control

Experiment planning

Team collaboration

Education

BS/MS in Molecular Biology or related field

Tools

NGS instruments

Job description

Personalis in Fremont, California is seeking a hands-on molecular biology professional to join a multidisciplinary R&D team. You will operate NGS equipment, perform library preparation from real-world samples, and help develop precision oncology products used by pharma, biotech, and clinical partners.

Responsibilities include assay and workflow execution, DNA/RNA extraction, quality control (Qubit, TapeStation), sample prep for NGS, validation studies, SOP refinement, and meticulous