Senior Research Associate, Antibody Discovery

SystImmune, Inc.; Washington (District of Columbia); On-site; USD 70,000 - 90,000; Full time

Benefits offered by this job

Medical premiums

Dental premiums

Vision premiums

STD/LTD

401(k) with match

PTO 15 days

Holidays 11

Job summary

SystImmune, Inc. in Bothell, WA seeks a Senior Research Associate to join the Antibody Discovery Group, supporting the engineering of novel therapeutic antibodies.

The role is lab-based, focusing on BCR amplification, sequence analysis, and recombinant antibody expression in a fast-moving biopharma setting.

This onsite position offers opportunities to contribute to cutting-edge cancer therapeutics and to advance your career in a collaborative team.

Qualifications

• Bachelor or master’s in immunology, molecular biology, biochemistry or related field.
• 5+ years industry experience for Senior Research Associate (BA) or 3+ years with Master’s.
• 3+ years hands-on recombinant antibody expression experience.
• Strong molecular biology background; knowledge of antibody structure, humanization, production and purification preferred.
• NGS library prep and BCR repertoire analysis a plus.
• Experience in antibody discovery and development desirable.

Responsibilities

• Amplify BCR sequences from sorted B-cells.
• Select antibody candidates through BCR sequence analysis.
• Design, clone, and express recombinant monoclonal antibodies.
• Prepare detailed reports and presentations.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Skills

Molecular biology

PCR techniques

Antibody expression

NGS library prep

BCR analysis

Transfection

Cell culture

Antibody humanization

Data analysis

Education

Immunology or related field degree

Tools

Geneious

Discovery Studio

Job description

Company Overview

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

Position Overview

We are seeking a highly skilled and motivated Senior Research Associate to join our Antibody Discovery Group. The successful candidate will play a critical role in supporting the discovery of novel antibodies for therapeutic development. This is a laboratory-based role that utilizes various techniques, including BCR amplification, sequence analysis, and recombinant antibody expression. This position offers an exciting opportunity to work in a dynamic and innovative environment focused on the development of novel therapeutic antibodies.

This is a full-time onsite position in Bothell, WA.

Key Responsibilities

• Amplify BCR sequences from sorted B-cells.


• Select antibody candidates through BCR sequence analysis.


• Design, clone, and express recombinant monoclonal antibodies.


• Prepare detailed reports and presentations.


• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Required Skills & Qualifications

• Bachelor or master’s degree in Immunology, Molecular Biology, Biochemistry, or a related field.


• Senior Research Associate requires bachelor’s degree with 5+ years or master’s degree with 3+ years of industry experience.


• 3+ years of hands-on experience in recombinant antibody expression.


• Strong molecular biology background and experience.


• Knowledge of antibody structure, humanization, production, and purification is preferred.


• Hands-on experience in NGS library preparation and BCR repertoire analysis is a plus.


• Experience in antibody discovery and development is highly desirable.

Technical Skills

• Highly proficient in molecular biology techniques, including PCR (general, nested, etc.), cloning, plasmid DNA isolation, RNA isolation, and sequencing.


• Experience in eukaryotic cell transfection and culture.


• Hands-on experience in humanization of antibodies using various methods.


• Familiarity with sequence data analysis software and statistical tools (Geneious, Discovery Studio).

Soft Skills

• Effective communication skills, both written and verbal.


• Strong organizational and time management skills.


• Excellent problem-solving and troubleshooting abilities.


• Ability to work independently and as part of a team.

Compensation and Benefits

The expected base salary range for this position is $70,000 - $90,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills. While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

Benefits

• 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

Equal Opportunity Employer

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.