Senior Protein Scientist: Structure & Antibody Discovery

Kaztronix LLC; Wilmington (DE); On-site; USD 110,000 - 150,000; Full time

Job summary

Kaztronix LLCis seeking a driven Protein Chemist to accelerate gene‑to‑structure workflows and antibody discovery. You will design constructs, express proteins in multiple systems, and implement purification strategies to deliver high‑quality samples for structural studies and downstream assays.

You will collaborate with structural biologists, assay scientists, and engineers in a fast‑paced, cross‑functional setting, driving quality and innovation in drug discovery programs.

Qualifications

• PhD or Master’s with extensive protein chemistry and drug discovery experience.
• Hands-on expertise in recombinant protein expression and purification.
• Purification and QC of antibodies and fragments, including analytical methods.
• Ability to troubleshoot expression, purification, and stability challenges.

Responsibilities

• Independently design and optimize recombinant protein constructs for expression and downstream applications.
• Express proteins in mammalian, insect, and bacterial systems to maximize yield and quality.
• Develop purification workflows including affinity, ion exchange, and SEC.
• Purify antibodies and complexes; perform QC for purity and aggregation.
• Characterize proteins/antibodies with SEC-HPLC, DSF, BLI, SPR, and related techniques.
• Establish QC criteria for samples used in structural biology and assay development.
• Collaborate with cross-functional teams in a matrixed environment and manage multiple projects.

Skills

Protein chemistry

Recombinant expression

Protein purification

Biophysical characterization

Antibody purification

Analytical QC

Chromatography

Troubleshooting

Cross-functional collaboration

Communication

Education

PhD in Biochemistry/Biophysics/Protein Chemistry/Molecular Biology/Structural Biology

2+ years of relevant experience or Master's +5 years

Tools

Affinity chromatography

Ion-exchange chromatography

SEC/HPLC

DSF/thermal shift

BLI/SPR

Protein A/G purification

Job description

Kaztronix LLCis seeking a driven Protein Chemist to accelerate gene‑to‑structure workflows and antibody discovery. You will design constructs, express proteins in multiple systems, and implement purification strategies to deliver high‑quality samples for structural studies and downstream assays.

You will collaborate with structural biologists, assay scientists, and engineers in a fast‑paced, cross‑functional setting, driving quality and innovation in drug discovery programs.