Remote Senior Clinical Trial Manager - Gene Editing

Rippling, Inc.; Cambridge (MA); Remote; USD 165,000 - 185,000; Full time

Benefits offered by this job

Bonus potential

Equity

Health benefits

Parental leave 12 weeks

Parking or transit

401(k) match

Job summary

Arbor Biotechnologies in Cambridge, MA is seeking a Senior Clinical Trial Manager to lead day-to-day operations for early-phase gene-editing studies, partnering with sites, CROs, vendors, and internal teams to drive start-up, execution, and close-out.

You will manage timelines, budgets, trial documentation, risk mitigation, and regulatory submissions, with hands-on leadership in a fast-paced startup environment and the option to work remotely. Travel domestically and internationally as needed.

Qualifications

• Bachelor’s degree in a scientific, health-related, or related field.
• ≥6 years of progressive clinical operations experience.
• Experience managing early-phase studies; rare disease or CNS preferred.
• Experience with US and global trials across CROs and vendors.
• Knowledge of regulatory submissions and GCP/ICH guidelines.
• Strong leadership, planning, and communication skills.

Responsibilities

• Lead day-to-day clinical trial operations across studies, sites, CROs, vendors.
• Manage start-up, site activation, monitoring, and close-out activities.
• Own timelines, budgets, invoices, and vendor deliverables.
• Oversee trial master file quality and documentation for inspections.
• Review protocols, ICFs, CRFs, SAPs, CSRs, and study plans.
• Partner with cross-functional teams to drive study execution and milestones.
• Manage clinical sample logistics between patients, sites, and labs.
• Coordinate safety review boards and data monitoring committees; data cuts.
• Lead vendor review, onboarding, contracting, and oversight.
• Build relationships with sites, CROs, vendors, and investigators; plan meetings.
• Identify and resolve study risks and operational issues.
• Represent the company externally with partners and sites.
• Travel domestically and internationally as needed.

Skills

Clinical operations leadership

Vendor management

Budget management

Regulatory submissions

GCP/ICH knowledge

Cross-functional collaboration

Education

Bachelor's degree in a scientific field

Tools

Smartsheet

Microsoft Office

Job description

Arbor Biotechnologies in Cambridge, MA is seeking a Senior Clinical Trial Manager to lead day-to-day operations for early-phase gene-editing studies, partnering with sites, CROs, vendors, and internal teams to drive start-up, execution, and close-out.

You will manage timelines, budgets, trial documentation, risk mitigation, and regulatory submissions, with hands-on leadership in a fast-paced startup environment and the option to work remotely. Travel domestically and internationally as needed.