Senior Project Manager - CNS (North America)

Worldwide Clinical Trials; Clayton (NC); Remote; USD 110,000 - 160,000; Full time

Job summary

Worldwide Clinical Trials is seeking a Senior Project Manager CNS to lead Phase I–IV clinical trials with global reach. You will own study delivery from start-up through closeout, guiding cross-functional teams, vendors, and partners while maintaining quality, timelines, and budgets.

The role requires travel and collaboration with clients across regions. Ideal candidates have 7+ years in clinical project management, CNS trial experience, and strong knowledge of ICH GCP and regulatory

Qualifications

• Minimum 7 years of clinical project management experience.
• Experience leading CNS trials or CNS-focused programs preferred.
• Solid understanding of ICH GCP and global regulatory requirements.

Responsibilities

• Lead cross-functional project teams to deliver Phase I–IV CNS trials from start-up to closeout.
• Drive planning, execution, tracking, and risk management to meet timelines, quality, and budgets.
• Coordinate internal teams, external partners, and vendors for seamless execution.
• Serve as primary client contact and build trusted relationships to ensure satisfaction.
• Manage resources, identify gaps, and develop contingency plans to maintain momentum.
• Monitor financial performance and support revenue and budget targets.
• Promote collaboration and effective teamwork across global project teams.
• Ensure deliverables meet contractual requirements, client expectations, and SOPs.
• Drive continuous process improvements to enhance efficiency and quality.

Skills

Cross-functional leadership

Budget management

Project planning

Client relationship

GCP/ICH knowledge

Stakeholder management

English fluency

Job description

It is built by those who take pioneering, creative approaches and implement them with quality and excellence.

We are Worldwide Clinical Trials, and we are a global team of over 3,500+ experts, bright thinkers, dreamers and doers and, together, we are changing the way the world experiences CROs - in the best possible way.

Why Worldwide

Make an Impact as a Senior Project Manager at Worldwide

As a Senior Project Manager CNS, you will play a critical role in delivering Phase I-IV clinical trials that have local, regional, or global reach. You will take ownership of study delivery from start-up through closeout, ensuring projects are executed efficiently while meeting quality, timeline, and budget expectations.

In this highly visible role, you will serve as a key point of contact for clients, leading cross-functional teams and driving collaboration across internal stakeholders, external partners, and vendors. You will combine strategic thinking, operational oversight, and financial management to guide projects to success while fostering strong client relationships and supporting a culture of excellence, accountability, and continuous improvement.

This is a remote role open to candidates based in Central or Eastern Europe. Travel will be required on an as-needed basis, including domestic and international travel as required by project needs.

• Lead cross-functional project teams to deliver Phase I-IV clinical trials from start-up through closeout.
• Drive project planning, execution, tracking, and risk management to ensure successful delivery against timeline, quality, and budget objectives.
• Coordinate internal teams, external partners, and subcontractors to ensure seamless project execution.
• Serve as the primary client contact, building trusted relationships and ensuring high levels of client satisfaction.
• Manage project resources, identify potential gaps, and develop contingency plans to maintain project momentum.
• Monitor project financial performance and contribute to meeting assigned revenue and budget targets.
• Facilitate collaboration, resolve conflicts, and promote effective teamwork across global project teams.
• Ensure project deliverables meet contractual requirements, client expectations, and applicable clinical research standards and SOPs.
• Drive process improvements that enhance operational efficiency and quality across assigned projects.

Minimum 7 years of clinical pharmaceutical industry experience, including demonstrated clinical project management experience; alternatively, significant healthcare supervisory experience combined with clinical research experience in the pharmaceutical or CRO industry.

Proven experience leading multidisciplinary, cross-functional project teams and managing CNS clinical research projects is required for this role.

Strong understanding of project management principles, including scope, timelines, quality, resources, and cost management.

Solid financial acumen, including experience developing and managing project budgets.

Thorough knowledge of ICH Guidelines, Good Clinical Practice (GCP), and international regulatory requirements governing clinical development programs.

Experience using project management software and strong organizational, communication, negotiation, and stakeholder management skills.

Fluent in English, both written and verbal, and fluent in the local office language; valid passport and driver's license required, with willingness to travel domestically and internationally as needed.

At Worldwide Clinical Trials, we are committed to fostering an inclusive and equitable workplace by providing transparent compensation.

The salary range for this position is annually (For hourly paid positions, the stated salary range reflects hourly rates):

The final salary will be determined based on relevant experience, performance, education, and internal equity. We ensure pay equity and transparency and comply with all applicable labor laws. To view our other roles, check out our careers page at Discover a world of difference at Worldwide ! For more information on Worldwide, visit or connect with us on LinkedIn.