Senior Process Engineer, Small Molecule API — Remote

CRB; Kansas City (MO); Remote; USD 103,000 - 165,000; Full time

Benefits offered by this job

Comprehensive insurance

Annual incentive program

Job summary

CRB seeks a Senior Process Engineer specializing in small molecule manufacturing to lead API process development, scale-up, and optimization for diverse client programs. You will design, assess, and implement robust process solutions across PFDs, P&IDs, and mass/energy balances while ensuring regulatory alignment and project success.

You will mentor junior engineers, coordinate with cross-disciplinary teams, and contribute to capital project planning, vendor management, and startup activities in

Qualifications

• Bachelor’s or Master’s degree in Chemical Engineering or a related discipline (ABET-accredited).
• Minimum of 5 years of experience in small molecule process engineering, preferably in a consulting or client-facing role.
• Strong understanding of chemical synthesis, purification, and formulation processes.
• Experience in design firm or operating company settings within a related industry.
• Strong written and verbal communication skills.
• Intermediate experience with applicable industry and regulatory guidance and building codes.
• Advanced technical knowledge with small molecule API manufacturing equipment and utility systems.
• Experience designing and implementing engineering controls for containment of highly potent APIs.
• Experience with cGMP practices within regulated industries (FDA, EMA, JP, etc.).

Responsibilities

• Lead and support client projects focused on small molecule API process development, scale-up, and manufacturing optimization.
• Conduct site assessments, gap analyses, and provide recommendations for process improvements and compliance.
• Develop PFDs, P&IDs, and mass/energy balances.
• Translate client requirements into actionable design scope and document decisions, open issues, and action items.
• Identify and elevate scope changes or design deviations to project leadership.
• Collaborate with cross-functional teams including architecture, mechanical, electrical, and construction.
• Prepare technical reports, proposals, and presentations for internal and client stakeholders.
• Support capital project planning including feasibility studies and equipment selection.
• Ensure alignment with industry standards including cGMP, FDA, EMA, and ICH guidelines.
• Mentor junior engineers and design staff.
• Lead system design programming and planning with support from senior engineers.
• Participate in cross-discipline squad checks and drive overall project quality.

Skills

Small molecule manufacturing

Process design

Scale-up

Regulatory compliance

Effective communication

Education

ABET-accredited Chemical Engineering degree

Tools

PFDs

P&IDs

3D model reviews

Job description

CRB seeks a Senior Process Engineer specializing in small molecule manufacturing to lead API process development, scale-up, and optimization for diverse client programs. You will design, assess, and implement robust process solutions across PFDs, P&IDs, and mass/energy balances while ensuring regulatory alignment and project success.

You will mentor junior engineers, coordinate with cross-disciplinary teams, and contribute to capital project planning, vendor management, and startup activities in