Senior Process Chemistry Scientist – Drug Substance Development

Revolution Medicines, Inc.; Redwood City (CA); On-site; USD 170,000 - 212,000; Full time

Job summary

Revolution Medicines, Inc. is seeking an experienced process chemist to lead drug substance development for RAS-targeted programs at our Redwood City, CA headquarters.

The role requires a PhD in organic chemistry with 8+ years in pharmaceutical process development, including scale-up, technology transfer, and regulatory submissions. You will manage a small team and coordinate cross-disciplinary decisions with analytics, quality, manufacturing, and regulatory groups.

Qualifications

• PhD in organic chemistry with pharma process development exposure.
• Record of solving complex process chemistry problems.
• Experience supporting regulatory submissions.
• Leadership of scientific teams and coaching.

Responsibilities

• Personally design and execute pivotal experiments to resolve difficult chemistry problems, develop new methods, and test high‑impact scientific hypotheses.
• Lead investigations of complex reaction behavior, process variability, and impurity formation; establish recommendations for process control.
• Direct integrated process development across programs, establishing technical priorities and evaluating strategies.
• Manage a small group of scientists and research associates; develop capability through coaching and feedback.
• Lead cross‑disciplinary discussions with analytics, quality, manufacturing, regulatory, and supply chain partners.
• Direct laboratory scale-up and technology transfer to CDMOs, evaluate risks, and resolve manufacturing problems.
• Author and review process chemistry documentation in support of regulatory filings.
• Identify broader implications of findings for subsequent development and maintain safety and knowledge capture.

Skills

Advanced hands-on synthesis

Regulatory submission experience

Cross-disciplinary leadership

Analytical evidence interpretation

Effective communication

Education

PhD in Organic Chemistry

Job description

Revolution Medicines, Inc. is seeking an experienced process chemist to lead drug substance development for RAS-targeted programs at our Redwood City, CA headquarters.

The role requires a PhD in organic chemistry with 8+ years in pharmaceutical process development, including scale-up, technology transfer, and regulatory submissions. You will manage a small team and coordinate cross-disciplinary decisions with analytics, quality, manufacturing, and regulatory groups.