Scientist II, Process Chemistry

Revolution Medicines, Inc.; Redwood City (CA); On-site; USD 132,000 - 166,000; Full time

Job summary

Revolution Medicines, Inc. is hiring for a process development role in Redwood City, onsite.

You will own development of reactions and process steps, design experiments, and optimize routes and conditions to meet project objectives. The role requires a PhD in organic chemistry with 2+ years of related experience, strong hands-on skills in multistep synthesis, and proficiency with analytical tools and ELN/ChemDraw.

Qualifications

• PhD in organic chemistry with at least 2 years of related experience, including postdoctoral work.
• Independently design and execute process development studies and solve complex synthetic chemistry problems.
• Strong hands-on skills in multistep synthesis, reaction optimization, isolation, and characterization using NMR, chromatography, and mass spectrometry.
• Connect experimental results with process robustness, scale-up considerations, and project objectives.
• Experience leading a scientific workstream and providing technical guidance to colleagues.
• Clear scientific writing, collaboration, and proficiency with ELN, data analysis tools, and ChemDraw.

Responsibilities

• Own development of reactions and process steps to meet project objectives.
• Design and execute experiments to optimize routes and conditions.
• Investigate complex reaction behavior and impurity formation using mechanistic reasoning.
• Develop robust processes with parameter sensitivity, reproducibility, and impurity control.
• Plan laboratory studies and translate results for large-scale implementation.
• Prepare transfer procedures and work with CDMOs to resolve issues.
• Author process development reports and regulatory documentation; maintain ELN records.
• Provide scientific guidance to associates and address safety risks.

Skills

Process development

Multistep synthesis

NMR/MS/Chromatography

Data analysis tools

Guidance to colleagues

Education

PhD in Organic Chemistry

Tools

ChemDraw

Electronic Lab Notebook (ELN)

Job description

The Opportunity:

• Own the development of reactions, process steps, or development workstreams, setting experimental approaches and coordinating work to meet agreed project objectives.
• Design and execute experiments to evaluate alternative routes and optimize reactions, workup, isolation, and crystallization conditions.
• Investigate complex reaction behavior and impurity formation using mechanistic reasoning, experimental design, comparison of analytical data, and understanding relevant scientific literature.
• Develop robust processes by defining parameter sensitivity, reproducibility, impurity control, solubility limits, and other practical requirements for manufacturing.
• Plan and execute laboratory studies and translate results into recommendations for process implementation at large-scale.
• Prepare technology transfer procedures and work with external contract development and manufacturing organizations (CDMOs) to resolve implementation issues.
• Author process development reports and technical content supporting regulatory documentation; maintain complete electronic laboratory records.
• Provide scientific guidance to research associates, present recommendations to project teams, and identify and address laboratory and process safety risks.

Required Skills, Experience and Education:

• PhD in organic chemistry and at least 2 years of related experience, which may include postdoctoral research.
• Demonstrated ability to independently design and execute process development studies and solve complex synthetic chemistry problems.
• Strong hands‑on skills in multistep synthesis, reaction optimization, isolation, and characterization using NMR, chromatography, and mass spectrometry.
• Ability to connect experimental results with process robustness, scale‑up considerations, and project objectives.
• Experience taking responsibility for a defined scientific workstream and providing technical guidance to colleagues.
• Clear scientific writing, effective collaboration, and proficiency with electronic laboratory notebooks, data analysis tools, and ChemDraw.

Preferred Skills:

• Industry experience in pharmaceutical process development, laboratory scale‑up, crystallization, or technology transfer to CDMOs.
• Experience with design of experiments, automated laboratory reactors, cGMP manufacturing, or drug substance regulatory documentation.

#LI-CT1 #LI-Hybrid The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job‑related skills, experience, market dynamics, and relevant education or training.

Base Pay Salary Range $132,000—$166,000 USD

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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