Senior Principal Statistical Programmer — Remote Leader

WCG Clinical, Inc.; Lincoln (NE); Remote; USD 131,000 - 160,000; Full time

Job summary

WCG Clinical, Inc. is seeking a Senior Principal Statistical Programmer remote in the US to lead complex programming for clinical trials. The role combines hands-on SAS development with technical leadership and collaboration across biostatistics, data management, and study teams.

You will design, validate, and standardize outputs like datasets, tables, listings and figures, while advancing DMC macros and programming standards. Mentorship and strategic input to proposals are key responsibilities.

Qualifications

• Master’s degree required; equivalent combination considered in limited cases.
• 8–10 years of statistical programming experience in a clinical trial environment.
• Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
• Proficiency in R programming.
• Demonstrated experience with CDISC standards and regulatory requirements.
• Proven ability to independently lead complex programming efforts across studies.
• Experience mentoring staff and driving technical standards or best practices.

Responsibilities

• Serve as a senior technical expert in statistical programming across multiple studies.
• Design, develop, validate, and oversee complex programming deliverables (datasets, tables, listings, figures).
• Lead development and standardization of DMC macros and programming standards.
• Provide technical oversight to ensure quality, compliance, and consistency.
• Drive programming standards and process improvements across projects.
• Collaborate with biostatistics and study teams on complex trial designs and analyses.
• Mentor statistics programming staff and support skill development.
• Contribute technical input to proposals, planning, and scopes as needed.
• Partner with IT to support SAS environments and system validation.
• Ensure regulatory submission readiness and CDISC alignment.

Skills

SAS programming

R programming

CDISC standards

Technical leadership

Mentoring staff

Education

Master’s degree

Tools

SAS

R

CDISC

Job description

WCG Clinical, Inc. is seeking a Senior Principal Statistical Programmer remote in the US to lead complex programming for clinical trials. The role combines hands-on SAS development with technical leadership and collaboration across biostatistics, data management, and study teams.

You will design, validate, and standardize outputs like datasets, tables, listings and figures, while advancing DMC macros and programming standards. Mentorship and strategic input to proposals are key responsibilities.