Senior Principal Statistical Programmer (Remote)

WCG Clinical, Inc.; Salt Lake City (UT); Remote; USD 131,000 - 160,000; Full time

Job summary

WCG Clinical, Inc. in the United States (Remote) seeks a Senior Principal Statistical Programmer to lead complex programming initiatives and set standards across studies.

You will drive design, development, and validation of analysis datasets, tables, listings, and figures, while guiding cross-functional teams. The role requires 8–10 years of clinical trial statistics programming, expertise in SAS, R, and CDISC, and a track record of mentoring staff and delivering regulatory submissions.

Qualifications

• Minimum 8–10 years of statistical programming experience in a clinical trial environment.
• Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
• Proficiency in R programming is a must.
• Demonstrated experience with CDISC standards and regulatory requirements.
• Proven ability to independently lead complex programming efforts across studies.
• Experience mentoring staff and driving technical standards or best practices.
• Demonstrated ability to independently coordinate biostatistical projects, including planning and oversight of programming activities, with minimal direction from senior leadership.

Responsibilities

• Serve as a senior technical expert in statistical programming, providing guidance across multiple studies or functional areas.
• Design, develop, validate, and oversee complex statistical programming deliverables, including analysis datasets, tables, listings, and figures.
• Lead the development, validation, and continuous improvement of DMC macros and programming standards.
• Provide technical oversight and review of programming work to ensure quality, compliance, and consistency across deliverables.
• Drive the establishment and adoption of programming standards, best practices, and process improvements.
• Collaborate with biostatistics and study teams to support complex trial designs, analyses, and DMC reporting.
• Independently manage and prioritize programming activities across multiple studies or initiatives.
• Mentor and provide technical leadership to statistical programming staff, supporting skill development and best practices.
• Contribute technical expertise to proposals, project planning, and scope discussions as needed.
• Partner with IT and technology teams to support SAS environments, tools, and system validation efforts.
• Provide technical oversight for programming activities supporting regulatory submissions and inspection readiness.
• Ensure programming deliverables align with regulatory expectations, submission requirements, and CDISC standards.
• Influence programming approaches, standards, and best practices across multiple studies or programs.
• Serve as a technical escalation point for complex programming, data, or deliverable issues, leading resolution of highly complex or ambiguous challenges.
• Provide expert interpretation of statistical analysis plans (SAPs), protocols, and study documents, translating requirements into programming strategy.
• Champion process improvements, automation, and innovative approaches to enhance efficiency, scalability, and consistency of programming deliverables.
• Other duties as assigned by supervisor. These may, on occasion, be unrelated to the position described here.

Skills

SAS programming

R programming

Leadership/mentoring

Regulatory deliverables

Education

Master's degree in a relevant field

Tools

CDISC standards

Regulatory requirements

Job description

WCG Clinical, Inc. in the United States (Remote) seeks a Senior Principal Statistical Programmer to lead complex programming initiatives and set standards across studies.

You will drive design, development, and validation of analysis datasets, tables, listings, and figures, while guiding cross-functional teams. The role requires 8–10 years of clinical trial statistics programming, expertise in SAS, R, and CDISC, and a track record of mentoring staff and delivering regulatory submissions.