Senior Principal Scientist, Quantitative Biosciences

Merck; Boston (MA); On-site; USD 180,000 - 240,000; Full time

Job summary

Merck in Boston, MA is seeking a Senior Principal Scientist to provide scientific and strategic leadership for mass spectrometry-enabled discovery within the Quantitative Biosciences group.

The role shapes the application of MS and quantitative pharmacology across discovery programs, strengthens decision-making, and advances high-impact science through collaboration with local and global teams.

Responsibilities

• Lead the Boston MS group supporting in vitro and in vivo pharmacology.
• Shape strategy for MS-based assay development and quantitative pharmacology across programs.
• Develop and execute MS-based assays to inform mechanism and translational decisions.
• Provide guidance on assay selection, design, and data interpretation.
• Build connections across the Boston team and broader QB network.

Job description

Overview

We are seeking a Senior Principal Scientist to provide scientific and strategic leadership for mass spectrometry-enabled discovery within the Quantitative Biosciences group in Boston. This role will help shape the application of mass spectrometry and quantitative pharmacology across discovery programs, strengthen experimental decision-making, and advance high-impact science through close partnership with local and global teams.

Job Description

Senior Principal Scientist - Boston, MA

Overview

We are seeking a Senior Principal Scientist to provide scientific and strategic leadership for mass spectrometry-enabled discovery within the Quantitative Biosciences group in Boston. This role will help shape the application of mass spectrometry and quantitative pharmacology across discovery programs, strengthen experimental decision-making, and advance high-impact science through close partnership with local and global teams.

As a senior scientific leader in Quantitative Biosciences, you will lead the Boston mass spectrometry capability supporting in vitro and in vivo pharmacology, advise multidisciplinary project teams, and influence broader QB strategy. The successful candidate will combine deep technical expertise in mass spectrometry-based assay development with strong pharmacology insight, sound scientific judgment, and the ability to mentor scientists and drive cross-functional alignment.

In This Role, You Will

• Lead the Boston mass spectrometry group in support of in vitro and in vivo pharmacology needs and serve as a key scientific partner to discovery teams across QB.
• Shape strategy for mass spectrometry-enabled assay development, experimental design, data interpretation, and quantitative pharmacology applications across discovery programs.
• Partner with multidisciplinary project teams to develop and execute mass spectrometry-based assays that inform mechanism, potency, selectivity, exposure-response, and translational decision-making.
• Provide scientific guidance to bench scientists and project teams, supporting assay selection, study design, mechanistic interpretation, and data-driven recommendations.
• Build and strengthen connections across the local Boston team and