Senior Principal Applications Engineer Mass Spectrometry

Centillion Infotech LLC; Milpitas (CA); On-site; USD 140,000 - 190,000; Full time

Job summary

Centillion Infotech LLC invites an experienced Senior Principal Applications Engineer – Mass Spectrometry to lead advanced MS applications development and customer support. You will collaborate with engineering, product, and R&D teams to deploy high‑throughput workflows and robust analytical methods.

You will mentor engineers, optimize instrument performance, and drive new application development while staying abreast of HRMS and proteomics, metabolomics, and clinical research trends in

Qualifications

• Bachelor’s or Master’s degree in Chemistry, Biochemistry, Life Sciences, Engineering, Computer Science, or related field.
• 6–12 years of experience in Mass Spectrometry applications or related tech solutions.
• Strong hands‑on experience with LC‑MS, GC‑MS, and MS workflows.
• Expertise in method development, optimization, validation, and troubleshooting.
• Strong understanding of MS principles, instrumentation and data interpretation.
• Experience with cross‑functional teams including engineering, R&D, product management, and customers.
• Excellent communication and problem‑solving skills.

Responsibilities

• Provide advanced technical leadership for mass spectrometry applications and workflows.
• Develop, optimize, and validate analytical methods using LC‑MS, GC‑MS, and HRMS platforms.
• Lead customer engagements including demonstrations, proofs‑of‑concepts, troubleshooting and application support.
• Analyze complex analytical data and recommend workflow improvements.
• Collaborate with R&D, engineering, and product teams on enhancements and new developments.
• Support instrument evaluation, testing, validation, and performance optimization.
• Create technical documentation, notes, training materials, and best practices.
• Mentor junior engineers and provide technical guidance across teams.
• Identify customer challenges and translate requirements into technical solutions.
• Support field teams with advanced troubleshooting and escalations.
• Stay current with emerging trends in mass spectrometry and analytical sciences.

Skills

Mass spectrometry

Analytical instrumentation

Cross‑functional collaboration

Technical problem‑solving

Communication

Mentoring

Workflow optimization

Education

Bachelor's/Master's in Science/Engineering

Tools

LC‑MS

GC‑MS

HRMS

Mass spectrometry software

Data analysis tools

Job description

Job Summary

We are seeking an experienced Senior Principal Applications Engineer – Mass Spectrometry to provide advanced technical leadership in the development, optimization, and deployment of mass spectrometry applications. The ideal candidate will have strong expertise in analytical instrumentation, application development, customer support, and technical problem‑solving.

This role involves collaborating with customers, engineering teams, product management, and R&D teams to deliver innovative mass spectrometry solutions, improve application performance, and support complex scientific workflows.

Key Responsibilities

Provide advanced technical expertise and leadership for mass spectrometry applications and workflows.

Develop, optimize, and validate analytical methods using LC‑MS, GC‑MS, and high‑resolution mass spectrometry platforms.

Lead customer engagements including technical demonstrations, proof‑of‑concepts, troubleshooting, and application support.

Analyze complex analytical data and provide recommendations for workflow improvements.

Collaborate with R&D, engineering, and product teams on product enhancements and new application development.

Support instrument evaluation, testing, validation, and performance optimization.

Create technical documentation, application notes, training materials, and best practice guides.

Mentor junior engineers and provide technical guidance across application teams.

Identify customer challenges and translate requirements into effective technical solutions.

Support field teams with advanced troubleshooting and customer escalations.

Stay current with emerging technologies and industry trends in mass spectrometry and analytical sciences.

Required Qualifications

Bachelor’s or Master’s degree in Chemistry, Biochemistry, Life Sciences, Engineering, Computer Science, or related technical discipline.

6–12 years of experience in Mass Spectrometry applications, analytical instrumentation, or scientific technology solutions.

Strong hands‑on experience with LC‑MS, GC‑MS, and mass spectrometry workflows.

Expertise in method development, optimization, validation, and analytical troubleshooting.

Strong understanding of mass spectrometry principles, instrumentation, and data interpretation.

Experience working with cross‑functional teams including engineering, R&D, product management, and customers.

Excellent communication, technical presentation, and problem‑solving skills.

Preferred Skills

Experience with high‑resolution mass spectrometry (HRMS) platforms.

Knowledge of proteomics, metabolomics, pharmaceutical, biotechnology, or clinical research applications.

Experience with mass spectrometry data processing and analysis software.

Familiarity with laboratory workflows, automation, and scientific informatics systems.

Experience supporting enterprise customers, technical sales, or field applications engineering.

Leadership experience mentoring engineers or technical teams.

Technical Skills

• Mass Spectrometry (MS)
• LC‑MS / GC‑MS
• High Resolution Mass Spectrometry (HRMS)
• Analytical Method Development
• Instrument Optimization & Troubleshooting
• Scientific Data Analysis
• Laboratory Instrumentation
• Application Engineering
• Technical Documentation
• Scientific Software Platforms