Senior Principal Scientist, Clinical PK/Pharmacometrics

Immunome, Inc.; Bothell (WA); On-site; USD 186,000 - 212,000; Full time

Job summary

Immunome, Inc. in Bothell, WA is seeking a Principal Scientist, Clinical Pharmacology and Pharmacometrics to lead pharmacology strategy for late-stage and preclinical assets. You will integrate PK/PD, PBPK, and modeling to drive dose selection and program decisions across oncology programs.

The role requires a Ph.D. or PharmD with 2–5 years in regulated biotech, experience with ADCs or RLTs, and proficiency in modeling software. Collaboration with CROs and cross-functional teams is essential.

Qualifications

• Ph.D. or PharmD in a relevant scientific discipline.
• 2-5 years' experience in pharmaceutical/biotechnology industry in a regulated bioanalytical environment, preferably with multiple modalities, including small molecule, large molecule and ADC experience.
• Experience in noncompartmental and PBPK analyses and pharmacometric modeling and simulation oversight including use of WINNONLIN, NONMEM, MONOLIX or similar statistical modeling software
• Knowledge of R, R-shiny, SAS, MATLAB, NONMEM, MONOLIX, PBPK ( GastroPlus or Simcyp ) or similar modeling software and substantial experience integrating quantitative clinical pharmacology with oncology drug development strategy
• Familiarity with current global clinical pharmacology and pharmacometrics regulatory guidance.
• Experience in development of anti-cancer agents, preferably ADCs and/or RLTs.

Responsibilities

• Formulate and deliver CP&MS strategy for late-stage and early preclinical/clinical development assets.
• Apply pharmacokinetic/pharmacodynamics (PK/PD), physiologic based PK (PBPK) and pharmacometric modeling & simulation (M&S) approaches to characterize drug absorption and disposition and assess the dynamics of drug effect to inform dose selection and go/no-go decisions.
• Work with preclinical and clinical CROs and company scientists to conduct and monitor clinical pharmacology studies, maintain study records and ensure study completion along program timelines.
• Contribute and drive program strategy, study design, protocol preparation, study execution, data review/analysis, report preparation and regulatory document preparation.

Skills

Excellent written/oral communication

Oncology drug development

PK/PD modeling

PBPK modeling

Cross-functional collaboration

Regulatory strategy

Education

Ph.D. or PharmD in a relevant scientific discipline

Tools

WINNONLIN

NONMEM

MONOLIX

R

R-shiny

SAS

MATLAB

PBPK software (GastroPlus or Simcyp)

Job description

Immunome, Inc. in Bothell, WA is seeking a Principal Scientist, Clinical Pharmacology and Pharmacometrics to lead pharmacology strategy for late-stage and preclinical assets. You will integrate PK/PD, PBPK, and modeling to drive dose selection and program decisions across oncology programs.

The role requires a Ph.D. or PharmD with 2–5 years in regulated biotech, experience with ADCs or RLTs, and proficiency in modeling software. Collaboration with CROs and cross-functional teams is essential.