Oncology Clinical PK/Pharmacometrics Scientist II

Immunomeinc; Bothell (WA); On-site; USD 140,000 - 172,000; Full time

Job summary

Immunome, Inc. is seeking a Scientist II, Clinical Pharmacology and Pharmacometrics in Washington to lead PK/PD strategy for late-stage and early development assets. You will apply PK/PD, PBPK and modeling to inform dose selection, and collaborate with CROs and internal teams on study design and regulatory documents.

Ideal candidates hold a Ph.D. or PharmD with oncology drug development experience, including ADCs, and strong communication to drive cross-functional programs.

Qualifications

• Ph.D. or PharmD in a relevant scientific discipline (clinical pharmacology, pharmacometrics or closely related scientific discipline).
• 0-2+ years' experience in pharmaceutical/biotechnology industry in regulated bioanalytical environment, preferably with multiple modalities, including small molecule, large molecule and ADC experience.
• Experience in noncompartmental and PBPK analyses and pharmacometric modeling and simulation oversight including use of WINNONLIN, NONMEM, MONOLIX or similar statistical modeling software
• Knowledge of R, R-shiny, SAS, MATLAB, NONMEM, MONOLIX, PBPK (gastroplus or Simcyp) or similar modeling software and substantial experience integrating quantitative clinical pharmacology with oncology drug development strategy
• Familiarity with current global clinical pharmacology and pharmacometrics regulatory guidance.
• Experience in development of anti-cancer agents, preferably ADCs and/or RLTs.

Responsibilities

• Formulate and deliver CPMS strategy for late-stage and early preclinical/clinical development assets.
• Apply PK/PD, PBPK and pharmacometric modeling to characterize drug exposure and inform dose selection.
• Collaborate with preclinical and clinical CROs and company scientists to conduct studies and ensure timelines.
• Contribute to program strategy, study design, data review, reports and regulatory documentation.

Skills

Clinical pharmacology

Pharmacokinetics

PBPK

Pharmacometrics

Regulatory strategy

Oncology drug development

Education

Ph.D. or PharmD

Tools

WINNONLIN

NONMEM

MONOLIX

R

R-shiny

SAS

MATLAB

GastroPlus/Simcyp PBPK

Job description

Immunome, Inc. is seeking a Scientist II, Clinical Pharmacology and Pharmacometrics in Washington to lead PK/PD strategy for late-stage and early development assets. You will apply PK/PD, PBPK and modeling to inform dose selection, and collaborate with CROs and internal teams on study design and regulatory documents.

Ideal candidates hold a Ph.D. or PharmD with oncology drug development experience, including ADCs, and strong communication to drive cross-functional programs.