Senior Oligonucleotide Process Transfer Advisor

Lilly Group; Indianapolis (IN); On-site; USD 131,000 - 211,000; Full time

Benefits offered by this job

Company bonus

401(k) and retirement benefits

Comprehensive benefits package

Job summary

Lilly is seeking an experienced scientist to lead oligonucleotide process transfers from development to pilot plant operations at the Lilly Medicine Foundry in Indiana. You will shape cGMP manufacturing for gram-to-kilogram quantities for clinical supply, acting as the site's technical authority on oligonucleotide processing and enabling rapid, scalable transfer across programs.

Your role requires cross-functional collaboration with CMC, Product R&D, Manufacturing, and Quality, driving

Qualifications

• BS/MS/PhD in Chemistry, Biochemistry, Chemical/Biochemical Engineering or related
• 20+ years with BS, 15+ with MS, or 2+ with PhD in oligonucleotide product/process development or related roles

Responsibilities

• Set strategy and direction for oligonucleotide transfers across programs.
• Define scale-up approaches for synthesis and purification from early-phase R&D.
• Serve as technical authority on oligonucleotide operations (synthesis, purification, TFF, lyophilization).
• Partner with safety and process engineering to shape procedure evaluation standards.
• Translate analytical data into strategic recommendations for program and site leadership.
• Represent process chemistry challenges to senior leadership and cross-functional teams.
• Drive plant readiness assessment across synthesis, cleavage, purification, TFF and lyophilization.

Skills

Oligonucleotide process

Analytical data interpretation

Cross-functional collaboration

Technical leadership

Communication skills

Education

Chemistry/biochemistry/chemical engineering degree

Tools

HPLC/UPLC

LC-MS

GC

TFF

Job description

Lilly is seeking an experienced scientist to lead oligonucleotide process transfers from development to pilot plant operations at the Lilly Medicine Foundry in Indiana. You will shape cGMP manufacturing for gram-to-kilogram quantities for clinical supply, acting as the site's technical authority on oligonucleotide processing and enabling rapid, scalable transfer across programs.

Your role requires cross-functional collaboration with CMC, Product R&D, Manufacturing, and Quality, driving