Senior Mass Spectrometry Proteomics Scientist

QuantumCell; South San Francisco (CA); On-site; USD 180,000 - 240,000; Full time

Benefits offered by this job

Competitive compensation

Equity opportunity

Conference support

Job summary

QuantumCell is building a groundbreaking mass-spectrometry-enabled proteomics platform to decode neuronal protein networks. We seek a Senior/Principal Analytical Scientist to own the MS function from instrument procurement to automated operation, interfacing analytical chemistry, cell biology, automation, and AI teams.

You will lead method development, high-throughput workflows, and data analysis collaboration, shaping data for AI models and Virtual Cell.

Qualifications

• Ph.D. in Analytical Chemistry, Biochemistry, Proteomics, Chemical Biology, or a closely related discipline.
• 5+ years hands-on experience operating high-resolution MS
• Expert-level proficiency with Orbitrap-based and/or TIMS-based instruments
• Expert command of nanoflow and microflow LC-MS/MS
• Hands-on experience with quantitative proteomics strategies (TMT, LFQ, SILAC) and differential abundance analysis
• Proficiency with major proteomics data analysis platforms
• Strong quantitative and data literacy; able to engage with bioinformatics and AI teams on data structures, quality metrics, and statistical models

Responsibilities

• Lead instrument market evaluation for neuronal protein profiling.
• Define vendor-neutral MS specifications and procurement.
• Oversee MS lab facility layout and safety for neuronal lysates.
• Develop high-throughput proteomics workflows for comparing genotypes.
• Collaborate with automation engineers to integrate MS with robotics.
• Own MS data processing and contribute to AI-ready datasets.
• Mentor junior scientists and contribute to IP/publications

Skills

Mass spectrometry-based proteomics

Orbitrap/ TIMS instruments

Nanoflow LC-MS/MS

Quantitative proteomics (TMT, LFQ, SIL

Education

Ph.D. in Analytical Chemistry/Biochemistry/Proteomics

Tools

Spectronaut

DIA-NN/OpenSWATH

LIMS integration

Job description

QuantumCell is building a groundbreaking mass-spectrometry-enabled proteomics platform to decode neuronal protein networks. We seek a Senior/Principal Analytical Scientist to own the MS function from instrument procurement to automated operation, interfacing analytical chemistry, cell biology, automation, and AI teams.

You will lead method development, high-throughput workflows, and data analysis collaboration, shaping data for AI models and Virtual Cell.