Senior Mass Spectrometry Scientist, Drug Discovery

BeOne Medicines Ltd.; San Carlos (CA); On-site; USD 165,000 - 207,000; Full time

Benefits offered by this job

Medical benefits

401(k) plan

Paid time off

Job summary

BeOne Institute in San Carlos, CA, seeks a Principal Scientist to drive cutting-edge mass spectrometry research, enabling emerging therapeutic modalities and transformative drug discovery programs at the interface of biology, chemistry, and technology development.

You will lead MS-based screening, proteomics, and analytical workflows, mentor teams, and advance MS platforms, ensuring robust data generation and actionable insights for multidisciplinary programs.

Qualifications

• Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 6+ years (Ph.D.), 8+ years (M.S.), or 10+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. highly preferred.
• Deep expertise in mass spectrometry, with demonstrated hands‑on experience operating, maintaining, troubleshooting, and optimizing LC-MS instrumentation.
• Strong experience developing and implementing mass spectrometry‑based screening and proteomics workflows.
• Demonstrated ability to apply mass spectrometry to address complex biological questions and generate mechanistic insights
• Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation.
• Experience developing and optimizing sample preparation, chromatography, and MS methods to enable sensitive, robust, and reproducible biological assays.
• Strong data analysis and interpretation skills, with the ability to extract meaningful biological insights from complex mass spectrometry datasets
• Demonstrated ability to independently troubleshoot analytical challenges and develop creative solutions to enable new applications and research capabilities
• Ability to partner effectively with scientists across biology, chemistry, and other disciplines to translate biological questions into fit-for-purpose mass spectrometry approaches
• Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non‑technical audiences
• Be able to work on‑site in San Carlos, CA

Responsibilities

• Contribute creatively to the scientific direction of the Institute by ideating, challenging, and advancing bold, high-impact research opportunities.
• Design and execute innovative research programs that leverage mass spectrometry to address important biological questions, enable emerging therapeutic modalities, and create new capabilities for drug discovery.
• Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism-of-action studies, and biological pathway interrogation.
• Drive the evaluation and implementation of emerging mass spectrometry technologies, workflows, and applications to expand scientific and technical capabilities.
• Lead the scientific operation and continuous advancement of mass spectrometry platforms, ensuring robust analytical performance and high-quality data generation.
• Analyze, interpret, and communicate complex mass spectrometry datasets, translating results into actionable biological and drug discovery insights.
• Partner closely with scientists across biology, chemistry, and other disciplines to develop fit-for-purpose analytical strategies and advance multidisciplinary research programs.
• Maintain high-quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields.

Skills

Mass spectrometry

LC-MS

Proteomics

Data analysis

Biology knowledge

Education

Ph.D. in Analytical Chemistry / Biochemistry

Ph.D. preferred

Tools

Orbitrap systems

Q-TOF

LC-MS instrumentation

Job description

BeOne Institute in San Carlos, CA, seeks a Principal Scientist to drive cutting-edge mass spectrometry research, enabling emerging therapeutic modalities and transformative drug discovery programs at the interface of biology, chemistry, and technology development.

You will lead MS-based screening, proteomics, and analytical workflows, mentor teams, and advance MS platforms, ensuring robust data generation and actionable insights for multidisciplinary programs.