Senior Mass Spectrometry Lead Scientist – Bioforensics

BNBI; Frederick (MD); On-site; USD 90,000 - 150,000; Full time

Job summary

NBACC at Fort Detrick conducts advanced mass spectrometry to identify toxins in forensic samples, supporting national biodefense. The role develops and validates MS methods, operates MALDI TOF and Orbitrap systems, and ensures accurate LIMS documentation.

You’ll mentor staff, draft SOPs, and lead projects with a strong emphasis on safety and quality. The position requires a scientific degree with substantial MS experience, proficiency in data analysis tools, and the ability to adapt to diverse

Qualifications

• Bachelor of Science (or equivalent) in a scientific discipline with 6+ years related experience or a Master’s with 4+ years experience.
• Experience with mass spectrometry instrumentation such as LC-MS/MS and MALDI TOF; proteomics/metabolomics experience desirable.
• Experience with sample preparation techniques (protein digestion, SDS-PAGE, solid phase extraction, liquid-liquid extraction).
• Ability to analyze and interpret mass spectrometry data using tools such as Proteome Discoverer, Compound Discoverer, MassHunter, Skyline, MaxQuant, FragPipe and MS-Dial; Python/R a plus.
• Advanced scientific proficiency in laboratory functions; ability to identify issues and improve protocols.

Responsibilities

• Develops, validates, and conducts MS methods and assays for identifying biological threat agents and toxins.
• Operates and maintains MALDI TOF, UPLC, nanoLC, triple quadrupole, and Orbitrap mass spectrometers.
• Drafts SOPs and protocols; mentors staff on safe procedures and LIMS documentation.
• Leads MS projects and improves technical and team results.
• Maintains accurate LIMS records and supports QA/QMS improvements.
• May serve as Lab Space Manager or BSAT designee.
• Adapts to new assignments and prioritizes tasks under pressure.

Skills

Mass spectrometry

Data interpretation

Informatics tools

Python/R

Communication

Project mentoring

Education

Bachelor's degree in a scientific field

Master's degree in a related field

Tools

LC-MS/MS

MALDI TOF

UPLC

Orbitrap

SOPs

Job description

NBACC at Fort Detrick conducts advanced mass spectrometry to identify toxins in forensic samples, supporting national biodefense. The role develops and validates MS methods, operates MALDI TOF and Orbitrap systems, and ensures accurate LIMS documentation.

You’ll mentor staff, draft SOPs, and lead projects with a strong emphasis on safety and quality. The position requires a scientific degree with substantial MS experience, proficiency in data analysis tools, and the ability to adapt to diverse