Senior LC-MS Scientist - Protein Analytics

MilliporeSigma; St. Louis (MO); On-site; USD 106,000 - 158,000; Full time

Job summary

MilliporeSigma in St. Louis, MO, is seeking a Senior Scientist to join the Analytical R&D Department.

You will lead the development of LC-MS assays for quantifying proteins in complex mixtures and perform advanced characterization of large biomolecules such as mAbs, multispecifics, and ADCs. This multidisciplinary team delivers analytical support to product development, manufacturing, and special projects, collaborating across functions to enable innovative science with impact.

Qualifications

• BS in Chemistry or related field with 5-7+ years of hands-on LC-MS experience.
• Advanced methods for sample preparation for large biomolecules LC-MS.
• Ability to work independently and in a team, with effective communication.

Responsibilities

• Lead development of LC-MS assays for quantitation of proteins in complex mixtures.
• Perform advanced characterization of large biomolecules including monoclonal antibodies, multispecifics, and ADCs.
• Provide high-level analytical support to product development scientists in R&D, manufacturing, and project teams.

Skills

LC-MS platforms

Team collaboration

Sample preparation for large biom Mole

Education

BS in Chemistry or related field

Master’s degree in related field

PhD in related field

Tools

MALDI-MS

UNIFI

BioPharma Finder

Mascot

Scaffold

Thermo mass spectrometers

Sciex

Waters

Agilent

Job description

MilliporeSigma in St. Louis, MO, is seeking a Senior Scientist to join the Analytical R&D Department.

You will lead the development of LC-MS assays for quantifying proteins in complex mixtures and perform advanced characterization of large biomolecules such as mAbs, multispecifics, and ADCs. This multidisciplinary team delivers analytical support to product development, manufacturing, and special projects, collaborating across functions to enable innovative science with impact.