Scientist 2 - Analytical Development

MilliporeSigma; Rockville (MD); On-site; USD 88,000 - 133,000; Full time

Benefits offered by this job

Health insurance

Paid time off (PTO)

Retirement contributions

Bonus potential

Job summary

MilliporeSigma is seeking a Scientist 2 - Analytical Development to lead the development and validation of new analytical methods. You will serve as the SME in method development/validation, ensuring robustness and readiness for implementation to strengthen the portfolio and meet market needs.

Responsibilities include leading method development, optimizing assays, training analysts, and ensuring cGMP compliance across diverse modalities such as mAbs, gene therapy products, ADCs, and viral

Qualifications

• Ph.D. in a scientific discipline with 3+ years of lab experience
• M.S. with 5+ years of lab experience
• B.S. with 7+ years of lab experience

Responsibilities

• Lead development and implementation of new analytical methods.
• Design, optimize, and troubleshoot analytical assays.
• Perform hands-on execution and technical leadership across modalities (mAbs, cell/gene therapy, ADCs, mRNA, viral vectors).
• Prepare/ review protocols, reports, SOPs, and laboratory records.
• Transfer GMP assays to routine team and provide training.

Skills

Analytical thinking

Communication

Time management

Collaboration

Leadership

Coaching

Education

Ph.D. in Analytical Chemistry/Chemistry/Biology

M.S. in Analytical Chemistry/Chemistry/Biology

B.S. in Analytical Chemistry/Chemistry/Biology

Tools

Excel

Oracle

LIMS

BRIQS

Word

Job description

Work Your Magic with us! Start your next chapter and join MilliporeSigma.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role

As a Scientist 2 - Analytical Development at MilliporeSigma you will lead the development and validation of new analytical methods that expand the current service portfolio and address identified market and client needs. Serving as the primary subject matter expert (SME) in analytical method development/validation, you will ensure new methods are robust, standardized, and ready for implementation to strengthen portfolio capabilities and address market-driven client needs.

Key Responsibilities

• Lead development and implementation of new analytical methods that expand laboratory capabilities and address gaps in current service offerings.
• Design, optimize, and troubleshoot analytical assays to ensure they are fit-for-purpose and aligned with phase-appropriate regulatory expectations.
• Perform hands‑on execution and technical leadership across a broad range of modalities, including monoclonal antibodies (mAbs), cell and gene therapy products, antibody‑drug conjugates (ADCs), mRNA therapeutics, and viral vectors.
• Keep current on relevant scientific literature, new technologies/capabilities, and support their implementation, as appropriate.
• Identify areas for improvement in current assays and propose and implement solutions.
• Act as SME in analytical methods and provide guidance to analysts and study managers.
• Apply laboratory techniques and skills to complete experiments designed to address a variety of specific problems.
• Prepare/ review protocols, reports, SOPs, laboratory records, tech specifications, and other related documents.
• Execute analytical methods in the lab for assay development/validation.
• Perform testing in accordance with SOPs and regulations (cGMP).
• Transfer GMP assays to the routine team and provide training to analysts, study managers, report writers, and QA.
• Operate and maintain lab equipment as required by SOPs and testing procedures.
• Utilize applicable computer programs during testing and routine tasks (i.e. Word, Excel, Oracle, LIMS, BRIQS, etc.).
• Lead general change control and resolve deviations by completing event records.
• Contribute ideas and suggestions to improve standard laboratory techniques, protocols, processes, and equipment.
• Maintain strong communication skills to effectively interact with internal and external stakeholders.
• Perform other duties as assigned.

Who You Are

Minimum Qualifications:

• Ph.D. in a scientific discipline (e.g., Analytical Chemistry, Chemistry, Biology, etc.), with 3+ years of professional lab experience .

OR

• Master’s Degree in a scientific discipline (e.g., Analytical Chemistry, Chemistry, Biology, etc.), with 5+ years of professional lab experience.

OR

• Bachelor’s Degree in a scientific discipline (e.g., Analytical Chemistry, Chemistry, Biology, etc.), with 7+ years of professional lab experience.

Preferred Qualifications

• Experience with:
  • Liquid Chromatography (HPLC; e.g., SEC, RP, IEX, and residual testing).
  • Mass Spectrometry (Intact Molecular Weight, Peptide Mapping, Disulfide Mapping, Glycan Profiling, N-/C-Terminal Sequencing).
  • Capillary Electrophoresis Methods (CE-SDS, cIEF).
  • Compendial assays and alternative methods (e.g., container closure integrity-related methods).
  • Particle sizing and characterization methods (e.g., DLS).
  • Mass photometry.
• Experience developing or implementing standardized analytical methods that expand laboratory service capabilities.
• Experience in method development in a pharmaceutical laboratory.
• Excellent oral and written communication skills demonstrated through presentations/seminars, oversight of projects, implementation of new services, etc.
• Excellent time management skills.
• Ability to succeed through collaboration and independently.
• High level of initiative and leadership capabilities.
• Effective coaching and training skills for complex and highly technical work.

Pay Range for this position: $88,300 - $132,500/year

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job‑related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here.

What we offer:

We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!