Senior Scientist

MilliporeSigma; St. Louis (MO); On-site; USD 106,000 - 158,000; Full time

Job summary

MilliporeSigma in St. Louis, MO, is seeking a Senior Scientist to join the Analytical R&D Department.

You will lead the development of LC-MS assays for quantifying proteins in complex mixtures and perform advanced characterization of large biomolecules such as mAbs, multispecifics, and ADCs. This multidisciplinary team delivers analytical support to product development, manufacturing, and special projects, collaborating across functions to enable innovative science with impact.

Qualifications

• BS in Chemistry or related field with 5-7+ years of hands-on LC-MS experience.
• Advanced methods for sample preparation for large biomolecules LC-MS.
• Ability to work independently and in a team, with effective communication.

Responsibilities

• Lead development of LC-MS assays for quantitation of proteins in complex mixtures.
• Perform advanced characterization of large biomolecules including monoclonal antibodies, multispecifics, and ADCs.
• Provide high-level analytical support to product development scientists in R&D, manufacturing, and project teams.

Skills

LC-MS platforms

Team collaboration

Sample preparation for large biom Mole

Education

BS in Chemistry or related field

Master’s degree in related field

PhD in related field

Tools

MALDI-MS

UNIFI

BioPharma Finder

Mascot

Scaffold

Thermo mass spectrometers

Sciex

Waters

Agilent

Job description

Work Your Magic with us! Start your next chapter and join MilliporeSigma. Ready to explore, break barriers, and discover more? We know you’ve got big plans - so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role

The Senior Scientist will join the Analytical R&D Department at MilliporeSigma at our Life Sciences R&D facility in St. Louis. In this role, you will be part of an active, multidisciplinary group of scientists dedicated to providing high level analytical support to product development scientists in R&D, manufacturing groups, and special project teams. You will be expected to lead development of LC-MS assays for the quantitation of proteins in complex mixtures. Additionally, you will perform advanced characterization of large biomolecules including monoclonal antibodies, multi-specifics, and antibody drug conjugates.

Who You Are

Minimum Qualifications

• BS in Chemistry or related field plus 5-7+ years of experience with demonstrated hands-on proficiency with advanced instrumentation, with high resolution and/or triple quadrupole LC-MS platforms OR a master’s degree with 3-5+ years of stated above experience, OR a PhD with 0-1+ years of stated above experience
• Advanced experience with a variety of enzymatic and chemical methods of sample preparation for large biomolecule LC-MS, such as digestion, enrichment, depletion, and labelling or related
• Experience working and communicating effectively both independently and in a team-oriented environment

Preferred Qualifications

• Experience in absolute quantitation of proteins and antibodies by Multiple Reaction Monitoring (MRM) and/or Parallel Reaction Monitoring (PRM) mass spectrometry
• Experience in bottom up, middle up/down, and/or top-down protein LC-MS workflows
• Experience with specific workflows such as non-reduced and reduced intact mass analysis, peptide mapping, disulfide mapping, Post-Translational Modifications (PTM) characterization, glycosylation profiling, and/or free thiol analysis
• Experience with bioinformatics related to the quantitation and characterization of large biomolecules such as UNIFI, BioPharma Finder, Mascot, and Scaffold
• Proficiency in a variety of instrument platforms such as Thermo, Sciex, Waters, and Agilent mass spectrometers
• Hands-on experience with MALDI-MS

Role must be based in St. Louis, MO

Pay Range for this position: $105,500 - $158,300. The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites.

What we offer:

We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!