Senior In Vivo Pharmacology Associate

Abiologics; Boston (MA); On-site; USD 81,000 - 107,000; Full time

Job summary

Abiologics, Inc. is seeking a highly motivated Senior Research Associate to join the Pharmacology team in the Watertown, MA area. The role focuses on hands-on rodent in vivo studies and coordination with CROs to advance the Synteins platform and pipeline.

The candidate will contribute to in vitro and ex‑vivo pharmacology activities, including molecular and cell biology assays and histology, while collaborating across design‑make‑test teams to drive project progression.

Qualifications

• BS in Biology or related discipline with 5–7 years of relevant research experience, or MS with 3–5 years of relevant experience, ideally in a biotech or pharmaceutical setting.
• Independent experience with rodent in vivo dosing and handling techniques with expertise in multiple routes of substance administration (e.g., PO, IP, IV, SC).
• Experience in tissue dissection and preparation for RNA, protein analysis, and histology, including fixation and embedding.
• Demonstrated ability to execute or learn various molecular and cell biology techniques, such as ELISA, Western blot, qPCR, cell-based functional assays, and flow cytometry.
• Proficiency with software such as Excel, GraphPad Prism, and PowerPoint for experimental documentation and data analysis/presentation.
• Strong organizational and analytical problem-solving skills, with meticulous attention to detail and industry-level experience with best practices related to data documentation and integrity.
• Demonstrated ability to work independently and collaboratively across highly skilled, cross-functional teams in a fast-paced, entrepreneurial, and technically complex environment.

Responsibilities

• Conduct in vivo (mouse) studies to characterize and assess the function, pharmacokinetics, and biodistribution of Synteins, with increasing ownership of study design and interpretation.
• Perform hands-on dosing of mice (including intravenous and other routes) and isolation/processing of mouse blood and tissues.
• Comply with IACUC regulations regarding animal welfare and care.
• Collect and prepare tissues for histology, including fixation and embedding.
• Execute and optimize lab procedures such as tissue lysis and cell isolation, ELISA, Western blot, RNA/DNA extraction, qPCR, and related cell/molecular biology assays supporting in vivo studies, including some cell culture.
• Coordinate with CROs to support the execution of external in vivo studies, including formulation and shipment of compounds.
• Analyze, interpret, and accurately document study and assay results in an electronic lab notebook and present findings in internal meetings.
• Apply troubleshooting and data analysis skills to resolve issues and improve study quality and throughput.
• Collaborate with the Pharmacology team and cross-functionally to support lead optimization and platform advancement.

Skills

Rodent in vivo dosing

Molecular biology techniques

ELISA

Western blot

qPCR

Flow cytometry

Cell culture

Excel

GraphPad Prism

PowerPoint

Education

BS in Biology or related field

MS in Biology or related field

Tools

Excel

GraphPad Prism

PowerPoint

Job description

Abiologics, Inc. is seeking a highly motivated Senior Research Associate to join the Pharmacology team in the Watertown, MA area. The role focuses on hands-on rodent in vivo studies and coordination with CROs to advance the Synteins platform and pipeline.

The candidate will contribute to in vitro and ex‑vivo pharmacology activities, including molecular and cell biology assays and histology, while collaborating across design‑make‑test teams to drive project progression.