Senior In Vitro Model Scientist – Immunology

AbbVie; Worcester (MA); On-site; USD 110,000 - 150,000; Full time

Benefits offered by this job

Comprehensive benefits package

Job summary

AbbVie Immunology seeks a scientist to support the design, execution, and interpretation of in vitro studies on drug candidate molecules and target validation. The role involves biochemical and cellular assays, co-culture and 3D systems, and communicating results to the team.

The successful candidate will have a strong background in immunology, cell biology, and quantitative data analysis, with experience in ELISA/flow cytometry and automation to increase assay throughput.

Qualifications

• BS or MS in Biological science with focus in Immunology, Biochemistry, Molecular Biology, Cell Biology, or a related discipline with typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
• Proficiency in culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures, including differentiated cells and iPSCs, using standard tissue culture and transwell systems.
• Experience developing and applying complex in vitro models, including co-culture and advanced 3D cellular systems, to support discovery programs.
• Experience designing experiments to study cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release.
• Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high content microscopy, and related methodologies.
• Demonstrated motivation, strong attention to detail, scientific curiosity, and eagerness to learn novel in vitro pharmacology techniques.
• Strong background in statistics with proficiency in spreadsheets and curve-fitting software such as Microsoft Excel and GraphPad Prism.
• Skilled in leveraging automation to increase assay robustness, improve throughput, and enable miniaturization of experimental workflows.
• Highly collaborative and able to thrive in a fast-paced, cross-functional, multidisciplinary environment, with strong organizational, communication, and interpersonal skills.

Responsibilities

• Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human blood cells, cell lines and complex in vitro systems such as organoids or organ-on-chip models.
• Analysis, interpret and clearly communicate quantitative data.
• Conduct and organize activities and communicate through oral and written presentations.
• Read and apply relevant scientific literature.
• Maintenance of accurate and current records of research.

Skills

Biology

Immunology

Data analysis

Statistics

Communication

Education

BS/MS in Biological science

Tools

ELISA

MSD

alphaLISA

HTRF

PCR

Flow cytometry

High content imaging

Job description

AbbVie Immunology seeks a scientist to support the design, execution, and interpretation of in vitro studies on drug candidate molecules and target validation. The role involves biochemical and cellular assays, co-culture and 3D systems, and communicating results to the team.

The successful candidate will have a strong background in immunology, cell biology, and quantitative data analysis, with experience in ELISA/flow cytometry and automation to increase assay throughput.