Senior In Vitro ADME Scientist—LC-MS/MS Expert

CHEManager International; Exton (PA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Health insurance

Dental insurance

401(k) plan

Disability insurance

Life insurance

Job summary

Frontage Laboratories Inc. is seeking an experienced Senior/Principal Scientist to join the In Vitro ADME group in Exton, PA.

This laboratory-based role develops, executes, interprets, and reports a broad range of in vitro ADME studies to support drug discovery and IND-enabling programs. The candidate will design and perform assays such as metabolic stability, CYP inhibition, TDI, and induction, with LC-MS/MS-based analytics, and provide data interpretation and client-facing scientific summaries

Qualifications

• Ph.D. or MS in Pharmaceutical Sciences, Analytical Chemistry, Biochemistry, Pharmacology, or related discipline with more than 5 years of industry experience.
• Strong hands-on experience with multiple in vitro ADME assays.
• Extensive LC-MS/MS-based quantitative bioanalysis experience preferred.
• Strong troubleshooting and communication skills.
• Ability to manage multiple studies in a fast-paced CRO environment.

Responsibilities

• Design, perform, troubleshoot, and interpret a broad range of in vitro ADME studies including metabolic stability, CYP inhibition, time-dependent inhibition (TDI), CYP induction, reaction phenotyping, enzyme kinetics, plasma protein binding, blood-to-plasma partitioning, tissue binding, using LC-MS/MS-based analytical methods.
• Independently conduct routine and complex ADME assays while ensuring high-quality data generation and timely project completion.
• Perform sample preparation, LC-MS/MS analysis, data processing, and result interpretation.
• Prepare study protocols, technical reports, and scientific summaries.
• Troubleshoot experimental and analytical challenges and implement appropriate solutions.
• Maintain laboratory instruments and ensure compliance with SOPs, quality standards, and laboratory safety requirements.
• Support client discussions by providing scientific expertise in study design and data interpretation.

Skills

In vitro ADME assays

LC-MS/MS data interpretation

Troubleshooting

Data interpretation

Verbal communication

Education

Ph.D. or MS in Pharmaceutical Sciences/Analytical Chemistry/Biochemistry/Pharmacology

Tools

LC-MS/MS

Job description

Frontage Laboratories Inc. is seeking an experienced Senior/Principal Scientist to join the In Vitro ADME group in Exton, PA.

This laboratory-based role develops, executes, interprets, and reports a broad range of in vitro ADME studies to support drug discovery and IND-enabling programs. The candidate will design and perform assays such as metabolic stability, CYP inhibition, TDI, and induction, with LC-MS/MS-based analytics, and provide data interpretation and client-facing scientific summaries